Oncolytic Viruses on Drugs: Achieving Higher Therapeutic Efficacy

ACS Infectious Diseases
Michael PhanJean-Simon Diallo

Abstract

Over the past 20 years there has been a dramatic expansion in the testing of oncolytic viruses (OVs) for the treatment of cancer. OVs are unique biotherapeutics that induce multimodal responses toward tumors, from direct cytopathic effects on cancer cells, to tumor associated blood vessel disruption, and ultimately potent stimulation of anti-tumor immune activation. These agents are highly targeted and can be efficacious as cancer treatments resulting in some patients experiencing complete tumor regression and even cures from OV monotherapy. However, most patients have limited responses with viral replication in tumors often found to be modest and transient. To augment OV replication, increase bystander killing of cancer cells, and/or stimulate stronger targeted anti-cancer immune responses, drug combination approaches have taken center stage for translation to the clinic. Here we comprehensively review drugs that have been combined with OVs to increase therapeutic efficacy, examining the proposed mechanisms of action, and we discuss trends in pharmaco-viral immunotherapeutic approaches currently being investigated.

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Citations

Mar 23, 2019·Thoracic Cancer·Yang BaiXing Su
May 24, 2020·Communications Biology·Rozanne ArulanandamJean-Simon Diallo
Oct 1, 2020·Virology Journal·Paul BarrowMarco Lalle
May 10, 2019·Oncoimmunology·Maria Eugenia Davola, Karen Louise Mossman
Jun 19, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Anabel BergeronDebbie C Crans
Aug 18, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Abouzar BabaeiEhsan Arefian
Nov 25, 2020·Expert Opinion on Drug Discovery·Shunchuan Zhang, Samuel D Rabkin
Feb 3, 2021·Journal for Immunotherapy of Cancer·Harsimrat Kaur BirdiMichele Ardolino
Mar 12, 2021·Current Oncology·Vanessa InnaoAlessandro Allegra
Apr 3, 2021·Journal for Immunotherapy of Cancer·Dong Ho ShinJuan Fueyo
Nov 20, 2020·Molecular Therapy Oncolytics·Fanny TzelepisJean-Simon Diallo

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