Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer

Journal of Hematology & Oncology
Bowen LiuLihong Ye

Abstract

Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription factor HOXB13 is of great significance in TAM resistance. However, the regulation of HOXB13 in TAM-resistant breast cancer remains largely unexplored. Here, we were interested in the potential effect of HBXIP, an oncoprotein involved in the acceleration of cancer progression, on the modulation of HOXB13 in TAM resistance of breast cancer. The Kaplan-Meier plotter cancer database and GEO dataset were used to analyze the association between HBXIP expression and relapse-free survival. The correlation of HBXIP and HOXB13 in ER+ breast cancer was assessed by human tissue microarray. Immunoblotting analysis, qRT-PCR assay, immunofluorescence staining, Co-IP assay, ChIP assay, luciferase reporter gene assay, cell viability assay, and colony formation assay were performed to explore the possible molecular mechanism by which HBXIP modulates HOXB13. Cell viability assay, xenograft assay, and immunohistochemistry staining analysis were utilized to evaluate the effect of the HBXIP/HOXB13 axis on the facilitation of TAM resistance in vitro and in vivo. The analysis of the Kapl...Continue Reading

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Citations

May 30, 2019·Cancers·Gerardo BottiMonica Cantile
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengxi XiuRenhua Wan
Apr 8, 2021·Acta Pharmacologica Sinica·Fei-Fei XuLi-Hong Ye
Jul 4, 2021·Experimental and Molecular Pathology·Xingzhe LiuYanhua Xuan
Nov 16, 2021·Molecular Medicine Reports·Qianxue WuHongyuan Li

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Datasets Mentioned

BETA
GSE1456

Methods Mentioned

BETA
transfection
PCR
xenograft
xenografts
acetylation
Co-IP
ELISA
ChIP
confocal microscopy

Software Mentioned

Image
PhosphoSitePlus
SPSS
Graph Pad Prism
Microsoft Access
GOBO
Pro Plus

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