PMID: 53842Nov 1, 1975

Oncornavirus-like particles released from arginine-deprived human lymphoblastoid cell lines

Proceedings of the National Academy of Sciences of the United States of America
M KotlerY Becker

Abstract

Type-C RNA tumor virus particles were released from three different human lymphoblastoid cell lines after incubation in arginine-deficient medium. The released virus-like particles were characterized by (a) their ability to band in sucrose gradients at a density of 1.16-1.18 g/ml; (b) the presence of an RNA-directed DNA polymerase activity resembling that of the oncornaviruses; and (c) isolation of cores that band at a density of 1.26-1.27 g/ml in sucrose gradients. Examination of the arginine-deprived human lymphoblastoid cell line strain P3HR-1 by electron microscopy revealed the presence of C-type particles in the intracellular spaces.

References

Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H BalabanovaY Becker
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T W MakD Housman
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D W KufeS Spiegelman
Aug 15, 1973·Nature: New Biology·M KotlerY Becker
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W BaxtS Spiegelman
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T W MakJ E Till
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R HehlmannS Spiegelman
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A AdamsG Klein
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D W KufeS Spiegelman
Jun 9, 1971·Nature: New Biology·J RossS A Aaronson

Citations

Sep 1, 1976·Die Naturwissenschaften·P Chandra
Mar 15, 1977·International Journal of Cancer. Journal International Du Cancer·K NazerianR L Witter
Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·E KlucisP G Parsons
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·M PopovicM G Sarngadharan
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·A YanivK Perk

Related Concepts

Arginine hydrochloride
African Burkitt's Lymphoma
DNA, Viral
Leukemia
Genomic Hybridization
Retroviridae
RNA-Directed DNA Polymerase

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