Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway

Acta Biochimica Et Biophysica Sinica
Xiaotian ZhangFeng Cao

Abstract

It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was designed to determine the role of OSM in cardiomyocyte dedifferentiation and the progression of DCM. A mouse DCM model was established to evaluate the effects of OSM in vivo. Echocardiography was applied to determine cardiac function. Sirius red staining was used to detect fibrosis area. Transmission electron microscopy was used to evaluate mitochondria impairment. Real-time polymerase chain reaction and western blot analysis were performed to detect relative mRNA expressions and cardiomyocyte dedifferentiation-related protein expressions, respectively. OSM treatment induced similar impaired cardiac function and cardiac ultrastructure impairment to those detected in DCM mice. The expressions of dedifferentiation markers of cardiomyocyte (Runx1, and α-SM-actin) were up-regulated in the OSM-treated mice compared with those in the control group. To further demonstrate the important role of OSM, OSM receptor knockout (Oβ(ko)) mice were used. In Oβ(ko) mice, cardiomyocytes dedifferenti...Continue Reading

References

Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Jun 4, 2002·European Heart Journal·G D DispersynM Borgers
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Sep 30, 2003·Diabetes Care·Alain G BertoniFrederick L Brancati
Nov 4, 2006·The International Journal of Biochemistry & Cell Biology·Hae Young SongJae Ho Kim
Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Jan 22, 2008·Nature Immunology·Elaine Dzierzak, Nancy A Speck
Nov 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J HohensinnerJ Wojta
Mar 27, 2009·Journal of Cellular and Molecular Medicine·Paras Kumar MishraSuresh C Tyagi
Jun 23, 2009·Journal of Cellular and Molecular Medicine·Ronald B DriesenFrans C S Ramaekers
Mar 6, 2010·Annals of the New York Academy of Sciences·Heinrich TaegtmeyerDeborah Vela
Mar 26, 2010·Nature·Chris JoplingJuan Carlos Izpisúa Belmonte
Sep 15, 2010·PloS One·Yiqiang ZhangEduardo Marbán
Apr 17, 2013·Journal of Hematology & Oncology·Akintunde AkinleyeDelong Liu
Apr 24, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Vishalakshi ChavaliParas K Mishra

❮ Previous
Next ❯

Citations

Jul 31, 2018·Connective Tissue Research·Lukasz Stawski, Maria Trojanowska
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Xiaohu FanRichard Schulz
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Zhaoning WangEric N Olson
Mar 11, 2020·Cardiovascular Research·Alexandra RiddellTamara P Martin
Dec 5, 2020·Journal of Molecular and Cellular Cardiology·Yike ZhuRoger Foo
Jul 1, 2021·Journal of Cellular and Molecular Medicine·Dianhong ZhangBinbin Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.