PMID: 9425117Feb 28, 1998Paper

Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells

The Biochemical Journal
J CichyJ Travis

Abstract

Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines stimulate the production of alpha1-proteinase inhibitor (alpha1-PI) in hepatocyte-derived cells, only OSM is able to up-regulate levels of this inhibitor in epithelial cells originating from the lung. In this study we characterized human lung-derived epithelial-like HTB58 cells for their ability to synthesize alpha1-PI after treatment with IL-6, OSM and LIF. The results demonstrate that the resistance of HTB58 cells to the effects of IL-6 and LIF was not because of a lack of their individual functional receptors and suggest that OSM utilizes two different receptors, gp130/LIF receptor and gp130/OSM receptor, in lung-derived epithelial cells.

Citations

Mar 10, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A GrenierS Chollet-Martin
Jun 28, 2002·British Journal of Pharmacology·Amelia K ScaffidiDarryl A Knight
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K A O'HaraD A Knight
Jul 5, 2005·Expert Opinion on Investigational Drugs·K J KallenS Rose-John
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Apr 20, 1999·Toxicologic Pathology·J K LoyS K Durham
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