Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity

Journal of Cellular and Molecular Medicine
D SunErhe Gao

Abstract

Oncostatin M (OSM) exhibits many unique biological activities by activating Oβ receptor. However, its role in myocardial I/R injury in diabetic mice remains unknown. The involvement of OSM was assessed in diabetic mice which underwent myocardial I/R injury by OSM treatment or genetic deficiency of OSM receptor Oβ. Its mechanism on cardiomyocyte apoptosis, mitochondrial biogenesis and insulin sensitivity were further studied. OSM alleviated cardiac I/R injury by inhibiting cardiomyocyte apoptosis through inhibition of inositol pyrophosphate 7 (IP7) production, thus activating PI3K/Akt/BAD pathway, decreasing Bax expression while up-regulating Bcl-2 expression and decreasing the ratio of Bax to Bcl-2 in db/db mice. OSM enhanced mitochondrial biogenesis and mitochondrial function in db/db mice subjected to cardiac I/R injury. On the contrary, OSM receptor Oβ knockout exacerbated cardiac I/R injury, increased IP7 production, enhanced cardiomyocyte apoptosis, impaired mitochondrial biogenesis, glucose homoeostasis and insulin sensitivity in cardiac I/R injured diabetic mice. Inhibition of IP7 production by TNP (IP6K inhibitor) exerted similar effects of OSM. The mechanism of OSM on cardiac I/R injury in diabetic mice is partly assoc...Continue Reading

References

Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Craig S StumpK Sreekumaran Nair
Jun 18, 2003·Reviews of Physiology, Biochemistry and Pharmacology·M Tanaka, A Miyajima
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mary Elizabeth PattiLawrence J Mandarino
Apr 21, 2007·Methods in Cell Biology·Cristofol Vives-BauzaElena Garcia-Arumi
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sibylle JägerBruce M Spiegelman
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Sean M DonahoeElliott M Antman
Nov 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J HohensinnerJ Wojta
Sep 17, 2009·Apoptosis : an International Journal on Programmed Cell Death·Jun-Qiu SongYong-Fen Qi
May 25, 2011·European Heart Journal·Benoit RondeletLaurence Dewachter
Jul 2, 2011·Current Pharmaceutical Design·Victor M VictorAntonio Hernandez-Mijares
Dec 23, 2011·Current Pharmaceutical Design·Victor M VictorAntonio Hernandez-Mijares
May 29, 2012·Cardiovascular & Hematological Agents in Medicinal Chemistry·Indira Padmalayam

❮ Previous
Next ❯

Citations

Nov 6, 2015·Journal of Cellular and Molecular Medicine·Jianqiang HuDongdong Sun
Dec 3, 2015·Biochemical and Biophysical Research Communications·Shuhong SunHaichang Wang
Jul 23, 2015·Cytokine & Growth Factor Reviews·Heike M Hermanns
Oct 4, 2016·Biochemical and Biophysical Research Communications·Yuanyuan HaoAiqun Ma
Oct 26, 2016·Journal of Pineal Research·Jianqiang HuDongdong Sun
Nov 2, 2016·The Journal of Clinical Investigation·Qingzhang ZhuAnutosh Chakraborty
May 10, 2017·Journal of Pineal Research·Mingming ZhangDongdong Sun
Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Jane NaufahuRichard W A Mackenzie
Mar 8, 2018·The Journal of Biological Chemistry·Juan M Adrian-SegarraJochen Pöling
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Chunfang GuStephen B Shears
Jun 22, 2018·Scandinavian Journal of Immunology·Nathaniel R WestAhmed N Hegazy
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Xiaohu FanRichard Schulz
Jan 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruizhe WangWen Yuan
May 30, 2019·BioMed Research International·Liping WeiYue Xu
Dec 29, 2017·Biological Reviews of the Cambridge Philosophical Society·Anutosh Chakraborty
Feb 11, 2016·Biochemical Society Transactions·Stephen B Shears
Apr 17, 2018·Bulletin of Experimental Biology and Medicine·S V MichurinaI Yu Ishchenko
Mar 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandip MukherjeeAnutosh Chakraborty
Feb 27, 2021·Journal of Cardiovascular Medicine·Micaela GliozziVincenzo Mollace
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·S V MichurinaE L Zavjalov
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirko MininiMariano Bizzarri

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electron paramagnetic resonance
enzyme-linked immunosorbent assay
acetylation

Software Mentioned

SPSS

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.