Oncostatin M-stimulated apical plasma membrane biogenesis requires p27(Kip1)-regulated cell cycle dynamics

Molecular Biology of the Cell
Sven C D van IjzendoornDick Hoekstra

Abstract

Oncostatin M regulates membrane traffic and stimulates apicalization of the cell surface in hepatoma cells in a protein kinase A-dependent manner. Here, we show that oncostatin M enhances the expression of the cyclin-dependent kinase (cdk)2 inhibitor p27(Kip1), which inhibits G(1)-S phase progression. Forced G(1)-S-phase transition effectively renders presynchronized cells insensitive to the apicalization-stimulating effect of oncostatin M. G(1)-S-phase transition prevents oncostatin M-mediated recruitment of protein kinase A to the centrosomal region and precludes the oncostatin M-mediated activation of a protein kinase A-dependent transport route to the apical surface, which exits the subapical compartment (SAC). This transport route has previously been shown to be crucial for apical plasma membrane biogenesis. Together, our data indicate that oncostatin M-stimulated apicalization of the cell surface is critically dependent on the ability of oncostatin M to control p27(Kip1)/cdk2-mediated G(1)-S-phase progression and suggest that the regulation of apical plasma membrane-directed traffic from SAC is coupled to centrosome-associated signaling pathways.

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Citations

May 26, 2009·The Journal of Biological Chemistry·Kacper A WojtalSven C D van Ijzendoorn
Feb 15, 2008·Molecular Biology of the Cell·Delphine ThéardSven C D van IJzendoorn
Jan 18, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kacper A WojtalSven C D van Ijzendoorn
Aug 19, 2008·Biochimica Et Biophysica Acta·Ben N G Giepmans, Sven C D van Ijzendoorn
Sep 14, 2010·Trends in Cell Biology·Magdalena R GolachowskaSven C D van IJzendoorn
Mar 27, 2015·Genesis : the Journal of Genetics and Development·Xinchao PanThomas J Carroll
Jun 2, 2006·The Journal of Biological Chemistry·Yoshiyuki WakabayashiIrwin M Arias
Oct 12, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Munetaka OzekiKeiji Tamaki
Apr 26, 2006·Journal of Cell Science·Sven C D van Ijzendoorn

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