Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro

Arthritis and Rheumatism
C LangdonCarl D Richards

Abstract

To measure levels of oncostatin M (OSM) in the synovial fluid of rheumatoid arthritis (RA) patients and to examine the activities of human OSM in the regulation of human synovial fibroblast (HSF) production of chemokines and matrix metalloproteinases (MMP-1 and MMP-3) in vitro. We examined the levels of OSM in the synovial fluids of patients with arthritis by an enzyme-linked immunosorbent assay (ELISA). ELISA of cell culture supernatants and Northern blots were used to assess responses of HSF to interleukin-1alpha (IL-1alpha), OSM, and other members of the IL-6/leukemia inhibitory factor (IL-6/LIF) family of cytokines. We detected variable levels of OSM antigen in 9 of 10 RA patient synovial fluids, but levels were not detectable in 9 of 10 osteoarthritis (OA) patient fluids. Upon examining the responses of HSF in culture, OSM stimulated monocyte chemoattractant protein 1 (MCP-1), whereas RANTES secretion (regulated upon activation, normal T expressed and presumably secreted) was not altered by OSM alone. In IL-1alpha-induced cells, OSM costimulation further enhanced MCP-1 release, but inhibited the release of RANTES and IL-8. Other members of the IL-6/LIF family of cytokines did not show these effects. OSM induced a small ele...Continue Reading

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Citations

Nov 17, 2009·American Journal of Respiratory Cell and Molecular Biology·Cecilia M O'KaneJon S Friedland
Jul 9, 2010·Journal of Leukocyte Biology·J S Silver, C A Hunter
May 10, 2011·Arthritis Research & Therapy·Kiyoshi MigitaHiromi Ishibashi
Jun 4, 2019·Frontiers in Immunology·Nathaniel R West
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May 18, 2004·Arthritis and Rheumatism·Andrew CrossRobert J Moots
Jan 25, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Débora S FaffeStephanie A Shore
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·David C SmythCarl D Richards
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Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·X Liu, T H Piela-Smith
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Jan 2, 2014·ISRN Inflammation·Carl D Richards
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Jan 25, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Carl D Richards
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carrie LangdonCarl D Richards
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Oct 8, 2019·Expert Opinion on Therapeutic Targets·Sare VerstocktSéverine Vermeire

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