Ondansetron use in the pediatric emergency room for diagnoses other than acute gastroenteritis

Pediatric Emergency Care
Jesse J SturmDaniel A Hirsh

Abstract

Ondansetron is widely used in the pediatric emergency department (PED) for vomiting and acute gastroenteritis (GE). Little is known about the spectrum of its use in diagnoses other than acute GE. The objective of this study was to evaluate the spectrum of diagnoses for which ondansetron is used in the PED. Medical records from 2 tertiary care PEDs from January 2006 to December 2008 were retrospectively reviewed. Patients 3 months to 18 years of age given ondansetron in the PED were identified. Patients without a primary discharge diagnosis (based on International Classification of Diseases, Ninth Revision code) of vomiting or GE were defined as non-GE. Patient age, initial triage level (1 = lowest acuity, 5 = highest), route of administration (enteral vs parenteral), primary diagnosis, disposition, and prescription for ondansetron at discharge were recorded; GE and non-GE patients were compared based on age and triage acuity. There were 32,971 patients who received ondansetron in the PED; 12,620 (38%) were non-GE patients. Non-GE patients were older (8.3 vs 4.3 years, P < 0.001) and of higher average initial triage level (2.95 vs 2.33, P < 0.001) compared with GE patients. Within non-GE patients, 79% received ondansetron entera...Continue Reading

References

Apr 21, 2006·The New England Journal of Medicine·Stephen B FreedmanElizabeth C Powell
Aug 12, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christine M StorkLawrence H Brown
Feb 3, 2007·Alimentary Pharmacology & Therapeutics·H SzajewskaM Dylag
Apr 4, 2007·Alimentary Pharmacology & Therapeutics·R Fossmark, H Waldum
May 26, 2007·Paediatric Drugs·Alexander K C Leung, Wm Lane M Robson

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Citations

Jun 7, 2012·Pediatric Emergency Care·Nasim GhafouriF Lee Cantrell
Sep 25, 2012·The American Journal of Emergency Medicine·Jesse J SturmDaniel A Hirsh
Mar 18, 2016·Journal of Tropical Pediatrics·Khalid Ibrahim, Khalid Al Ansari
Dec 3, 2014·The Journal of Pediatrics·James S LeungStephen B Freedman
Aug 17, 2018·Journal of the American Association of Nurse Practitioners·Janessa M GravesJasmine Graham
Jul 1, 2014·Pediatric Emergency Care·Karen A KinnamanWilliam P Meehan
Nov 15, 2017·Pediatric Emergency Care·James M GrayMarissa A Hendrickson
May 16, 2020·Current Neurology and Neuroscience Reports·Elizabeth Troy, Marcy Yonker
Oct 31, 2020·Archives of Disease in Childhood·Christopher LowryStephen Mullen

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