Ondansetron versus metoclopramide, both combined with dexamethasone, in the prevention of cisplatin-induced delayed emesis. The Italian Group for Antiemetic Research

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

Abstract

The role of 5-HT3 receptor antagonists in the prevention of chemotherapy-induced delayed emesis is controversial. We compared ondansetron and metoclopramide, both combined with dexamethasone, in cisplatin-treated patients. Three hundred twenty-two patients who had been given > or = 50 mg/m2 of cisplatin were randomly assigned to receive, from days 2 to 4 after chemotherapy, oral ondansetron (8 mg twice daily) or oral metoclopramide (20 mg every 6 hours), both associated with intramuscular dexamethasone (8 mg twice on days 2 and 3, and 4 mg twice on day 4). Patients received the same intravenous prophylaxis for acute emesis: ondansetron 8 mg and dexamethasone 20 mg. Nausea and vomiting were assessed daily until day 6 after chemotherapy. According to the intention-to-treat principle, 318 patients were assessable. Known prognostic factors were similar in the two treatment groups. Complete protection from delayed vomiting and nausea was achieved by 62.0% and 43.7% of patients treated with ondansetron and by 60.0% and 53.7% of those receiving metoclopramide (no significant differences). Patients who vomited in the first 24 hours achieved the lowest complete protection from delayed emesis. In these patients, ondansetron offered bette...Continue Reading

Associated Clinical Trials

Citations

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J GrallaD G Pfister
Aug 10, 2001·Medical and Pediatric Oncology·L L DupuisM L Greenberg
Aug 7, 2002·Internal Medicine Journal·N Bartlett, B Koczwara
Aug 8, 2002·International Journal of Palliative Nursing·Ruth Cooper, Peter Gent
Nov 27, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mark G KrisEnzo Ballatori
Apr 21, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Suthinee IthimakinApirom Laocharoenkeat
Feb 11, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yutaka KubotaTaeko Kitano
Jul 2, 1999·Anesthesia and Analgesia·J J WangY Y Chia
May 31, 2002·Expert Opinion on Investigational Drugs·Peter S Loewen
Mar 6, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alessandra FabiFrancesco Cognetti
Aug 31, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Enzo BallatoriRobert R Deuson
Jun 22, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Enzo BallatoriRobert Deuson
Jun 22, 1999·The New England Journal of Medicine·M E Camire
Jan 7, 2010·Bulletin du cancer·A Mailliez, J Bonneterre
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RoilaF Zerilli

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