One-carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats

BJU International
Parisa MohammadiMohammad H Nasr-Esfahani

Abstract

To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. Surgical varicocoele was induced in adult male Wistar rats and resulted in significant damage to the testis and sperm cells measured at 2 and 4 months after surgery. At 2 months after surgery, rats received a 2-month oral supplementation in support of the one-carbon cycle containing B vitamins (B2, B3, B6, folic acid and B12), N-acetyl-cysteine, zinc, small amounts of vitamin E, and a natural source of betalains and quercetine (Condensyl® ; Parthenogen SAGL, Lugano, Switzerland and Nurilia SARL, Lyon, France). One-carbon cycle supplementation, compared to untreated controls, significantly improved the morphometric characteristics of testis (P < 0.05), sperm concentration, motility and abnormal morphology (P < 0.001), sperm chromatin condensation (aniline blue staining, P < 0.05), sperm DNA damage (acridine orange staining, P < 0.05) and sperm lipid peroxidation (BODIPY C11, P < 0.001). The improvement in both nuclear condensation and DNA damage an...Continue Reading

References

Dec 1, 1987·Fertility and Sterility·R MieussetH Grandjean
Jul 5, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vered ElgazarWilliam F Silverman
Sep 30, 2006·Fertility and Sterility·Samira Barbosa LimaAgnaldo Pereira Cedenho
Nov 14, 2006·Human Reproduction Update·I M W EbischR P M Steegers-Theunissen
Mar 1, 2007·Molecular Human Reproduction·R John AitkenEileen A McLaughlin
Apr 12, 2007·Reproductive Biomedicine Online·Yves J R MénézoMoncef Benkhalifa
Aug 9, 2007·Andrologia·U LevingerG N Bachar
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Nov 1, 2007·International Journal of Andrology·M H Nasr-EsfahaniM Tavalaee
Feb 26, 2008·BJU International·Yuichi SakamotoMasato Fujisawa
Mar 3, 2009·Advanced Drug Delivery Reviews·Bernadett Kalmar, Linda Greensmith
May 20, 2011·BJU International·Camile Garcia BlumerAgnaldo Pereira Cedenho
Jun 21, 2011·Asian Journal of Andrology·Francesco LombardoAndrea Lenzi
Jun 8, 2012·Andrologia·M MotieiM-H Nasr-Esfahani
Oct 12, 2012·Oxidative Medicine and Cellular Longevity·Juan G ReyesRicardo D Moreno
Nov 10, 2012·Reproductive Sciences·Kiran Singh, Deepika Jaiswal
May 30, 2014·The World Journal of Men's Health·Ashok AgarwalStefan S du Plessis
Jul 22, 2014·Molecular Reproduction and Development·Afsoon Atrian AfiyaniMohammad Hossein Nasr-Esfahani
Jul 31, 2014·Reproductive Biology and Endocrinology : RB&E·Maurizio DattiloYves Menezo
Feb 16, 2015·Reproductive Biomedicine Online·Jinxiang WuLiuxia You
Mar 10, 2015·Systems Biology in Reproductive Medicine·Mahsa BahreinianMohammad H Nasr-Esfahani
May 26, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ali CyrusMehrdad Moghimi
Sep 25, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hajar KhosravanianNarges Khosravanian
Jan 15, 2016·Asian Journal of Andrology·Harshit Garg, Rajeev Kumar
Apr 15, 2017·Frontiers in Bioscience (Scholar Edition)·Shilpa Bisht, Rima Dada
Jul 5, 2017·Nature Reviews. Urology·Christian Fuglesang S JensenMikkel Fode

❮ Previous
Next ❯

Citations

Feb 15, 2020·Systems Biology in Reproductive Medicine·Patrycja SkowrońskaKrzysztof Łukaszuk
Aug 14, 2019·Molecular Nutrition & Food Research·Lawrence MabasaRabia Johnson
May 1, 2020·Oxidative Medicine and Cellular Longevity·Niloofar SadeghiMohammad H Nasr-Esfahani
Aug 18, 2020·Oxidative Medicine and Cellular Longevity·Mahshid HosseiniMohammad H Nasr-Esfahani
Aug 21, 2020·Andrologia·Mahshid HosseiniMohammad Hossein Nasr-Esfahani
Oct 10, 2020·Reproductive Biomedicine Online·Behzad AbbasiMohammad H Nasr-Esfahani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.