Dec 10, 2015

One-carbon metabolism and epigenetics: understanding the specificity

Annals of the New York Academy of Sciences
Samantha J Mentch, Jason W Locasale


One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.

Mentioned in this Paper

Metabolic Process, Cellular
DNA Methylation [PE]
Histone antigen
Protein Methylation
Metabolic Networks
Hmt antigen
Metabolic Networks and Pathways
Histone Methylation
Regulation of Biological Process

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

© 2020 Meta ULC. All rights reserved