Dec 10, 2015

One-carbon metabolism and epigenetics: understanding the specificity

Annals of the New York Academy of Sciences
Samantha J Mentch, Jason W Locasale

Abstract

One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.

Mentioned in this Paper

Metabolic Process, Cellular
DNA Methylation [PE]
Histone antigen
Protein Methylation
Metabolic Networks
Hmt antigen
Metabolic Networks and Pathways
Histone Methylation
Regulation of Biological Process
Protoplasm

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