PMID: 12146005Jul 31, 2002Paper

One case of locally advanced breast cancer in which multidisciplinary treatment, chiefly, therapy with preoperative intraarterial infusion of docetaxel (TXT), was successful

Gan to kagaku ryoho. Cancer & chemotherapy
Tomoaki HaradaK Satake


We herein report 1 case in which hormone therapy and neoadjuvant chemotherapy by local intraarterial infusion were conducted for locally advanced breast cancer, and were revealed to be useful in terms of local control. Administration of doxifluridine (5'-DFUR: Furtulon) (1,200 mg/day, 5 day continuous dosing followed by 2 day washout) and medroxyprogesterone acetate (MPA: Hysron H) (1,200 mg/day) was followed by chemotherapy consisting of intraarterial infusion of 100 mg of docetaxel (TXT: Taxotere), once monthly, via the left internal thoracic artery and left lateral thoracic artery. As a result, marked shrinkage of tumors was confirmed. Under these circumstances, left standard radical mastectomy plus skin grafting were performed. While under treatment, no serious adverse events were observed, and the patient made satisfactory progress after surgical procedure. She thus left hospital in a positive frame of mind.

Related Concepts

Taxoltere metro
Antineoplastic Chemotherapy Protocols
Antineoplastic Agents, Phytogenic
Mammary Neoplasms, Human
Noninfiltrating Intraductal Carcinoma
Infusions, Regional Arterial
Medroxyprogesterone 17-Acetate, (6 beta)-Isomer

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