One-dimensional collective migration of a proliferating cell monolayer

Soft Matter
Pierre RechoPhilippe Marcq

Abstract

The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address recent in vitro experiments on cell monolayers, which show that the advancement of the leading edge relies on cell proliferation and protrusive activity at the tissue margin. Within a simple viscoelastic mechanical model amenable to detailed analysis, we identify a key parameter responsible for tissue expansion, and we determine the dependence of the monolayer velocity as a function of measurable rheological parameters. Our results allow us to discuss the effects of pharmacological perturbations on the observed tissue dynamics.

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Citations

Jan 18, 2017·Soft Matter·C Blanch-MercaderJ Casademunt
Mar 2, 2018·PLoS Computational Biology·Yohei KondoShin Ishii
Aug 22, 2017·Soft Matter·C Blanch-Mercader, J Casademunt
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Sep 27, 2020·Bulletin of Mathematical Biology·Ryan J MurphyMatthew J Simpson
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Jun 13, 2018·Royal Society Open Science·Sham TliliFrançois Graner
Apr 2, 2019·Physical Review Letters·Ricard AlertJaume Casademunt
Aug 30, 2017·Soft Matter·Shunsuke Yabunaka, Philippe Marcq
Sep 28, 2017·Physical Review. E·Shunsuke Yabunaka, Philippe Marcq
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Oct 4, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ricard Alert, Jaume Casademunt
Aug 22, 2021·Seminars in Cell & Developmental Biology·Pedro Gómez-GálvezJavier Buceta

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