Oct 22, 2009

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells

Biophysical Journal
Shin InadaMark R Boyett

Abstract

Mathematical models are a repository of knowledge as well as research and teaching tools. Although action potential models have been developed for most regions of the heart, there is no model for the atrioventricular node (AVN). We have developed action potential models for single atrio-nodal, nodal, and nodal-His cells. The models have the same action potential shapes and refractoriness as observed in experiments. Using these models, together with models for the sinoatrial node (SAN) and atrial muscle, we have developed a one-dimensional (1D) multicellular model including the SAN and AVN. The multicellular model has slow and fast pathways into the AVN and using it we have analyzed the rich behavior of the AVN. Under normal conditions, action potentials were initiated in the SAN center and then propagated through the atrium and AVN. The relationship between the AVN conduction time and the timing of a premature stimulus (conduction curve) is consistent with experimental data. After premature stimulation, atrioventricular nodal reentry could occur. After slow pathway ablation or block of the L-type Ca(2+) current, atrioventricular nodal reentry was abolished. During atrial fibrillation, the AVN limited the number of action potent...Continue Reading

  • References29
  • Citations27

References

  • References29
  • Citations27

Citations

Mentioned in this Paper

Sinoatrial Node
Biochemical Pathway
Coronary Sinus Structure
Oscillators, Biological
Resting Potentials
Neurons
Action Potentials
Left Bundle Branch of His
Right Atrial Structure
Nerve Conduction Function

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