ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer

Biochemical and Biophysical Research Communications
Teresa Duda, R K Sharma

Abstract

The Ca(2+)-modulated ONE-GC membrane guanylate cyclase is a central component of the cyclic GMP signaling in odorant transduction. It is a single transmembrane spanning modular protein. Its intracellular region contains Ca(2+) sensor recognition domains linked to GCAP1 and to neurocalcin delta, and a catalytic module. These domains sense increments in free Ca(2+) and stimulate the catalytic module. The present study makes three significant mechanistic advancements. First, to date no ligand for the extracellular (ext) domain is known, for this reason ONE-GC has been deemed as an orphan receptor. The present study identifies its ligand. Uroguanylin stimulates ONE-GC through its ext domain. Second, so far no ligand is known that directly stimulates the catalytic module of any membrane guanylate cyclase. The presented evidence shows that in the presence of the semimicromolar range of free Ca(2+), neurocalcin binds to the catalytic module and stimulates ONE-GC. Thus, ONE-GC has trimodal regulation, two occurring intracellularly and one extracellularly. Third, guanylin, a urine odorant, does not directly stimulate ONE-GC. This challenges the proposed hypothesis that the guanylin odorant signal occurs via ONE-GC [T. Leinders-Zufall, R...Continue Reading

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Citations

Oct 3, 2008·Histochemistry and Cell Biology·Joerg FleischerHeinz Breer
Jan 24, 2009·Molecular and Cellular Biochemistry·Anuradha KrishnanRameshwar K Sharma
Jan 13, 2009·Molecular and Cellular Biochemistry·Teresa DudaRameshwar K Sharma
Dec 17, 2009·Molecular and Cellular Biochemistry·Sukanya KaranWolfgang Baehr
Nov 27, 2009·Molecular and Cellular Biochemistry·Frank Zufall, Steven D Munger
Nov 26, 2009·Molecular and Cellular Biochemistry·Dagang GuoXin-Yun Huang
May 27, 2008·Biochemistry·Venkateswar VenkataramanRameshwar K Sharma
Apr 1, 2009·Biochemistry·Dagang GuoXin-Yun Huang
Sep 24, 2008·Annual Review of Physiology·Steven D MungerFrank Zufall
Apr 30, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michelle R RebelloKathryn F Medler
Mar 25, 2009·FEBS Letters·Teresa Duda, Rameshwar K Sharma
Mar 27, 2010·Current Opinion in Neurobiology·Lisa Stowers, Darren W Logan
Dec 23, 2009·Biochemical and Biophysical Research Communications·Teresa Duda, Rameshwar K Sharma
Jul 31, 2009·Current Opinion in Neurobiology·Minmin LuoJi Hu
Apr 23, 2009·Journal of Neurochemistry·Marc Spehr, Steven D Munger
Jul 1, 2009·The Journal of Comparative Neurology·Cambrian Y LiuDavid S Koos
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Jun 18, 2010·The FEBS Journal·Teresa DudaRameshwar K Sharma
Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Liming SunMinmin Luo
Jul 20, 2010·Current Biology : CB·Steven D MungerKevin R Kelliher
Nov 28, 2012·European Journal of Pharmacology·Frank WunderMarkus Milde
Jul 30, 2014·Frontiers in Molecular Neuroscience·Rameshwar K Sharma, Teresa Duda
Mar 29, 2014·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Oct 4, 2016·Frontiers in Molecular Neuroscience·Rameshwar K SharmaClint L Makino
Oct 1, 2017·The EMBO Journal·Ying-Chi ChaoRuey-Bing Yang
Apr 1, 2016·Physiological Reviews·Michaela Kuhn
Nov 18, 2008·Journal of Neurogenetics·Minmin Luo
Dec 4, 2009·Molecular and Cellular Biochemistry·Rameshwar K Sharma
Nov 26, 2009·Molecular and Cellular Biochemistry·Rameshwar K Sharma, Teresa Duda
Mar 15, 2015·The Journal of Biological Chemistry·Teresa DudaClint L Makino
Nov 27, 2009·Molecular and Cellular Biochemistry·Teresa Duda
Nov 17, 2009·Molecular and Cellular Biochemistry·Anna Jankowska, Jerzy B Warchol
Jan 7, 2021·Cell and Tissue Research·Arthur D Zimmerman, Steven D Munger

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