One-hour postload plasma glucose and risks of fatal coronary heart disease and stroke among nondiabetic men and women: the Chicago Heart Association Detection Project in Industry (CHA) Study

Journal of Clinical Epidemiology
A J OrenciaJ Stamler

Abstract

Associations of baseline one-hour postload plasma glucose with 22-year coronary heart disease, stroke, cardiovascular diseases, and all cause mortality were assessed in five age-specific cohorts of nondiabetic men and women from the Chicago Heart Association Detection Project in Industry: 10,269 men ages 18-39 years; 7993 men ages 40-59 years; 1240 men ages 60-74 years; 6319 women ages 40-59 years; and 932 women ages 60-74 years. Plasma glucose was determined one hour after a 50-gram oral glucose load. Cox regression analyses were used to control for age and other covariates. Generally, higher glucose was significantly associated with mortality from coronary heart disease, stroke, cardiovascular diseases, and all cause mortality in men and women. This large longitudinal study provides evidence that one-hour postload plasma glucose in the absence of clinical diabetes at baseline apparently is an independent risk factor for fatal coronary heart disease and stroke in middle-aged and older nondiabetic men and women, and also for cardiovascular diseases and for all cause mortality.

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Citations

Oct 14, 2009·Diabetes Technology & Therapeutics·Christian Weber, Oliver Schnell
Oct 7, 2011·Current Medical Research and Opinion·Thomas R EinarsonMichiel Eric Henk Hemels
Aug 5, 2008·Diabetes Research and Clinical Practice·Norio HaradaNobuya Inagaki
Jul 6, 2007·Heart, Lung & Circulation·Kenneth Andrew Sikaris
Jul 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E E BlaakS Vinoy
Aug 22, 2006·Metabolism: Clinical and Experimental·Marc S Rendell, Lois Jovanovic
Jan 23, 2010·Metabolism: Clinical and Experimental·Jae Hoon MoonBong-Soo Cha
May 6, 2011·Diabetes Care·Eberhard StandlAntonio Ceriello
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Teresa Vanessa FiorentinoGiorgio Sesti
Jun 11, 2003·Hypertension·Miriam B RodinJeremiah Stamler
Jun 24, 2008·Expert Review of Cardiovascular Therapy·Stephen Fava
Feb 1, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lifei CaoGang Tian
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman
May 1, 2021·Journal of the Endocrine Society·Klara R KleinJohn B Buse
Nov 17, 2019·Food Research International·Lia Silveira AdrianoHelena Alves de Carvalho Sampaio
Nov 10, 2012·Journal of Agricultural and Food Chemistry·Abby S KlosterbuerJoanne L Slavin

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