PMID: 2496866Mar 25, 1989Paper

One hundred pregnancies after treatment with pulsatile luteinising hormone releasing hormone to induce ovulation

BMJ : British Medical Journal
R HomburgH S Jacobs

Abstract

To review treatment with pulsatile luteinising hormone releasing hormone in infertile women who do not ovulate and are resistant to clomiphene after 100 pregnancies achieved with this treatment. Retrospective analysis of 146 courses of treatment over 434 cycles. Infertility clinic. 118 Women whose failure to ovulate was due to idiopathic hypogonadotrophic hypogonadism (n = 39), amenorrhoea related to low weight (n = 17), organic pituitary disease (n = 15), or polycystic ovaries (n = 47). Dose of 15 micrograms luteinising hormone releasing hormone/pulse subcutaneously every 90 minutes given with a miniaturised pump throughout cycle monitored by ultrasound. Women with hypogonadotrophic hypogonadism had 48 courses, women with amenorrhoea related to low weight 23, women with organic pituitary disease 18, and women with polycystic ovaries 57. Follow up of 100 pregnancies achieved in 77 women during six years after introducing treatment. MEASUREMENTS and main results--One hundred pregnancies (seven multiple, 28 miscarriages). Cumulative rates of pregnancy were 93-100% at six months in women with idiopathic hypogonadotrophic hypogonadism, amenorrhoea related to low weight, and organic pituitary disease. In women with polycystic ovarie...Continue Reading

Associated Clinical Trials

Oct 3, 2006·Janet E. Hall, MD

References

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Jan 21, 1984·British Medical Journal·P MasonS White

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Citations

Apr 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M FilicoriR Pecorari
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·V D RamirezW W Lin
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Jun 19, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Raymond Hang Wun Li, Ernest Hung Yu Ng
Feb 13, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·S Christin-MaitreUNKNOWN Groupe Français des pompes à GnRH
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May 1, 2016·Reproductive Biology and Endocrinology : RB&E·Agathe DumontGeoffroy Robin
Jun 4, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Agathe DumontGeoffroy Robin
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·Z ShohamH S Jacobs
Feb 21, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Davinia M WhiteStephen Franks
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Jan 31, 2019·Endocrine Reviews·Jacques YoungNelly Pitteloud
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Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fotini ChristouFulgencio Gomez
Jun 23, 2005·Reproductive Biomedicine Online·Gamze Sinem CaglarSafaa Al-Hasani

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