One-lung ventilation during thoracoabdominal esophagectomy elicits complement activation

The Journal of Surgical Research
Jon A TsaiKristina Nilsson-Ekdahl

Abstract

One-lung ventilation (OLV) during thoracoabdominal esophagectomy may induce an inflammatory response that can contribute to the induction and propagation of frequently occurring postoperative respiratory distress. Markers of such a response might be detected in the pulmonary as well as in the systemic circulation. Inflammation and tissue damage may be key pathogenetic pathways and we hypothesized that 1-lung ventilation may induce an inflammatory cascade reflected by markers for such a response. Thirty patients with esophageal cancer were randomized to OLV (n = 16) or 2-lung ventilation (TLV; n = 14) during the thoracic part of the operation. Compounds involved in inflammation and coagulation were measured perioperatively and during the 1st, 2nd, 3rd, and 10th postoperative d. During the perioperative phase, the proinflammatory cytokine interleukin-6 and thrombin, measured as thrombin-antithrombin complexes, started to increase. Thrombin, which can induce complement activation, peaked at the end of surgery and interleukin-6 at the 1st to 2nd postoperative d, but there were no differences between the OLV and TLV groups. C3a and terminal complement complex (TCC) started to increase on the 2nd postoperative d and continued to do s...Continue Reading

References

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Citations

Apr 9, 2013·Future Oncology·Thomas J Lee, Robert C G Martin
Mar 3, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Jeong Jin LeeByung Hui Jun
Sep 10, 2015·Pediatric Research·Valérie DénervaudMatthias Roth-Kleiner
Mar 27, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K MoriY Seto
May 13, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D CasadoR Martí
Aug 14, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M LundJ A Tsai
Apr 10, 2013·Acta Cirúrgica Brasileira·Camila Ferreira LeiteRicardo Kalaf Mussi
May 13, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C FeeneyJ V Reynolds
Nov 26, 2010·Current Opinion in Anaesthesiology·Ju-Mei Ng
Jan 27, 2019·Asian Journal of Endoscopic Surgery·Hitoshi FujiwaraEigo Otsuji
Sep 4, 2019·Molecular Cancer·Zhiwei ChenShengtao Zhou
Dec 26, 2009·Current Opinion in Anaesthesiology

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