One particle, two targets: A combined action of functionalised gold nanoparticles, against Pseudomonas fluorescens biofilms

Journal of Colloid and Interface Science
Olivier HabimanaEoin Casey

Abstract

Attempts to deal with the problem of detrimental biofilms using nanoparticle technologies have generally focussed on exploiting biocidal approaches. However, it is now recognised that biofilm matrix-components may be targets for the disruption or dispersion of biofilms. Here, we show that the functionalization of gold nanoparticles with the enzyme, proteinase-K (PK) led to both biocidal and matrix disruption effects within Pseudomonas fluorescens biofilms and released cells. This study highlights the potential mechanisms underpinning the properties of Proteinase-K functionalized gold nanoparticles. With the emergence of biocide-resistant biofilm-forming organisms, novel nanoparticle strategies may provide the ideal solution for disrupting and inactivating biofilm cells, thereby minimising the use of biocides or antibiotics.

Citations

Aug 21, 2020·Nature Reviews. Microbiology·Jessa Marie V MakabentaVincent M Rotello
Jun 13, 2020·Frontiers in Microbiology·Rita M PintoPatrick Van Dijck
Oct 21, 2020·Expert Opinion on Therapeutic Patents·Annalisa BiancheraRuggero Bettini
Nov 19, 2020·Nanomaterials·Hoai My TranPhong A Tran
Feb 16, 2021·Frontiers in Microbiology·Ruchika Vinod JoshiRiti Mann
Dec 17, 2020·Frontiers in Microbiology·Mario F Gómez-NúñezAlberto N Peón
Aug 10, 2021·Chemical Communications : Chem Comm·Patricia BondiaJoaquim Torra
Aug 11, 2021·Polymers·Moupriya NagRina Rani Ray

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