One-phase synthesis of water-soluble gold nanoparticles with control over size and surface functionalities

Langmuir : the ACS Journal of Surfaces and Colloids
Eunkeu OhHedi Mattoussi

Abstract

We report a simple and efficient synthetic method to prepare gold nanoparticles (AuNPs) in aqueous phase using HAuCl(4) and poly(ethylene glycol) (PEG) ligands appended with bidentate anchoring groups. Our approach provides narrow size distribution nanocrystals over the size range between 1.5 and 18 nm; this range is much wider than those achieved using other small molecules and polymer ligands. The NP size was simply controlled by varying the molar ratio of Au-to-PEG ligand precursors. Further passivation of the as-prepared AuNPs permitted in situ functionalization of the NP surface with the desired functional groups. The prepared AuNPs exhibit remarkable stability in the presence of high salt concentrations, over a wide range of pHs (2-13), and a strong resistance to competition from dithiothreitol (DTT). These results are a clear manifestation of the advantages offered by our synthetic approach to prepare biocompatible AuNPs, where modular, multifunctional ligands presenting strong anchoring groups and hydrophilic PEG chains are used.

References

Nov 15, 2002·Chemical Communications : Chem Comm·Antonios G KanarasMathias Brust
Aug 12, 2004·Journal of the American Chemical Society·Raphaël LévyDavid G Fernig
Aug 25, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Chun-Hong KuoMichael H Huang
Mar 18, 2005·Journal of the American Chemical Society·H Tetsuo UyedaHedi Mattoussi
May 24, 2005·Nature Biotechnology·Carsten SönnichsenA Paul Alivisatos
Nov 25, 2005·Journal of the American Chemical Society·Irshad HussainMathias Brust
Dec 7, 2005·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Götz BucherWolfram Sander
Apr 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arun P WiitaJulio M Fernandez
Oct 13, 2006·The Journal of Physical Chemistry. B·Thomas PonsHedi Mattoussi
Nov 16, 2006·Annual Review of Physical Chemistry·Jie ZhengRobert M Dickson
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Zhenxin WangAndrew I Cooper
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Oct 25, 2007·Journal of the American Chemical Society·Kimihiro SusumuHedi Mattoussi
Jul 26, 2008·Nature Nanotechnology·Wen JiangWarren C W Chan
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
Jul 11, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Bing C MeiHedi Mattoussi

❮ Previous
Next ❯

Citations

Oct 31, 2012·ACS Applied Materials & Interfaces·Juliana TournebizeRaphaël Schneider
Feb 3, 2012·Chemical Reviews·Krishnendu SahaVincent M Rotello
Nov 8, 2012·Journal of the American Chemical Society·Megan E MuroskiGeoffrey F Strouse
Sep 11, 2012·ACS Nano·Madathumpady Abubaker Habeeb MuhammedHedi Mattoussi
Oct 1, 2011·Chemical Communications : Chem Comm·Abdul HameedShamsa Kanwal
Feb 27, 2014·ACS Applied Materials & Interfaces·Subhasish RoyArindam Banerjee
Sep 12, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Wang YaoJian-Ping Lang
Jul 23, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Samina NazirAlexander John MacRobert
Jun 11, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjuan CuiLong Jiang
Feb 22, 2011·Journal of Colloid and Interface Science·Ester FallettaPiero Baglioni
Oct 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Edward W ElliottJames E Hutchison
Jun 8, 2013·Photochemistry and Photobiology·Julia Pérez-Prieto
May 17, 2012·Electrophoresis·Carina HasenoehrlJames C Dabrowiak
Mar 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad NisarRashid Ali
Sep 4, 2015·Journal of the American Chemical Society·Madathumpady Abubaker Habeeb MuhammedJessica Rodríguez-Fernández
Apr 7, 2012·Journal of Colloid and Interface Science·Eunkeu OhAlan Huston
Jul 17, 2014·Chemical Society Reviews·Goutam PaluiHedi Mattoussi
Jun 3, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Dinesh MishraHedi Mattoussi
Jul 8, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Chul Soon ParkT Randall Lee
Jun 18, 2017·ACS Applied Materials & Interfaces·Mengzhen ZhaoLianhui Wang
Jun 5, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yingying LiQuquan Wang
Nov 15, 2018·Nanomedicine·Sébastien PenninckxStéphane Lucas
May 10, 2019·Nanotechnology·Guy ZuberManuela Chiper
Sep 19, 2019·Physical Chemistry Chemical Physics : PCCP·Dinesh MishraHedi Mattoussi
Nov 14, 2018·Nature Chemistry·Michelle J MacLeodJeremiah A Johnson
Feb 8, 2018·Nanoscale·Goutam PramanikPetr Cigler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.