"One pill, once daily": what clinicians need to know about Atriplatrade mark.

Therapeutics and Clinical Risk Management
Patrick G ClayMaurice Oelklaus

Abstract

As the number of persons chronically prescribed antiretrovirals has grown and the realization that antiretrovirals are required to be continued for life, pharmaceutical manufacturers have developed new classes of agents, improved the pharmacokinetics of marketed products through dosing reformulations, and in an effort to maximize success with respect to adherence, compiled into a single dosing unit all necessary elements for an antiretroviral regimen. Atriplatrade mark represents the first ever fixed-dose combination antiretroviral available. This article reviews currently available data on this agent, the impact of resistance on clinical use and implementation, as well as extensive descriptions of the pharmacokinetics, adverse effects and drug-interactions warranting consideration. Whether beginning in a naïve patient or switching from other regimens for tolerability issues, Atriplatrade mark represents a viable option. Its demonstrated advantages with respect to lipid and hematologic parameters and equivalent incidence of renal toxicity are tempered by the findings of bone mineral density decreases, however. Combining multiple mechanisms of action in a single dosing unit appears to improve efficacy, increase the likelihood fo...Continue Reading

Citations

Mar 15, 2018·Journal of the International Association of Providers of AIDS Care·Loraine Van Slyke, Mia Scott

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Methods Mentioned

BETA
sedation

Software Mentioned

INITIO
COMET
ATRIPLA

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