One Plus One Is Better Than Two: Cumulative Reproductive Outcomes Are Better after Two Elective Single Blastocyst Embryo Transfers Compared to One Double Blastocyst Embryo Transfer.

Journal of Human Reproductive Sciences
Vidhisha P MehtaManish R Banker

Abstract

The aim of this study is to compare cumulative in vitro fertilization-intracytoplasmic sperm injection outcomes following two elective single embryo transfer (eSET) versus one double embryo transfer (DET) using blastocyst(s). This was retrospective observational study. The study was conducted during January 2015-December 2015. Forty-one fresh + 25 frozen eSET versus 123 DET using self-oocytes and 68 fresh + 35 frozen eSET versus 184 DET using donor-oocytes were included in the study. All failing to achieve live birth after first eSET underwent frozen embryo transfer cycle with second blastocyst. Cumulative outcome after two eSET were compared with one DET. The analysis was performed by Chi-square and t-test. In self-oocytes group, higher but statistically nonsignificant cumulative clinical pregnancy rate (CPR) (58.5% vs. 57.7%, P = 0.92) and live birth rate (LBR) (48.7% vs. 44.7%, P = 0.65) with significantly lower multiple pregnancy rate (MPR) (4.2% vs. 45%, P = 0.0002) were obtained; whereas in donor-oocytes group, comparable cumulative CPR (73.5% vs. 65.7%, P = 0.24), significantly higher LBR (64.7% vs. 48.9%, P = 0.02) and significantly lower MPR (4% vs. 51.2%, P = 0.00005) were obtained after two eSET vs. one DET. In self-...Continue Reading

Citations

Jun 17, 2020·Human Fertility : Journal of the British Fertility Society·Caizhu WangHong Zhou
Mar 21, 2019·Current Opinion in Obstetrics & Gynecology·Andres Reig, Emre Seli
Jan 10, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Wei-Ya KongLei Yan

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Methods Mentioned

BETA
hormone replacement therapy
pregnancy test

Software Mentioned

SPSS

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