One-Pot Synthesis of α,β-Unsaturated γ-Lactones and Lactams via a Sequential trans -Hydroalumination and Catalytic Carboxylation of Propargyl Alcohols and Amines with Carbon Dioxide

Organic Letters
Woo-Jin YooShu Kobayashi

Abstract

A one-pot, sequential process that combines a trans-selective hydroalumination of propargyl alcohols and amines with a copper- or silver-catalyzed carboxylation reaction using carbon dioxide, followed by an acid-mediated intramolecular condensation step, led to the formation of a wide range of α,β-unsaturated γ-butyrolactones and lactams.

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