One-pot synthesis of 1,2,3-triazoles from boronic acids in water using Cu(II)-β-cyclodextrin complex as a nanocatalyst

Organic & Biomolecular Chemistry
Babak KaboudinTsutomu Yokomatsu

Abstract

We report here the one-pot synthesis of 1,2,3-triazoles of arylboronic acids in water. An efficient method has been developed for the synthesis of 1,2,3-triazoles via a one-pot reaction of an arylboronic acid with sodium azide in the presence of Cu(2)-β-CD (CD = Cyclodextrin) as a nanocatalyst in water followed by a click cyclization reaction with an alkyne at room temperature in air without any additives. This method is simple, rapid, and high yielding.

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Sep 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandro Mandoli
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