One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

Chemical Communications : Chem Comm
Ana Sousa-HervesMarcelo Calderón

Abstract

Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.

References

Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Oct 31, 2006·Advanced Drug Delivery Reviews·Omid C Farokhzad, Robert Langer
Aug 21, 2007·Biomaterials·Rajesh K Kainthan, Donald E Brooks
Feb 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas GantaMansoor Amiji
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Jun 30, 2009·Angewandte Chemie·Alexander V Kabanov, Serguei V Vinogradov
Mar 11, 2010·Advanced Materials·Marcelo CalderónRainer Haag
Mar 12, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zeng-Ying QiaoZi-Chen Li
Sep 12, 2012·Current Medicinal Chemistry·M Asadian-BirjandM Calderon
Dec 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dirk SteinhilberRainer Haag
Aug 21, 2013·Biomaterials·Jinrong PengZhiyong Qian
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Nov 15, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xuejiao ZhangRainer Haag
Jan 5, 2014·Advanced Drug Delivery Reviews·Elise LepeltierPatrick Couvreur

❮ Previous
Next ❯

Citations

Sep 15, 2017·Journal of Drug Targeting·Ummarah KanwalAbida Raza
Jun 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wioletta LiwinskaEwelina Zabost
Jan 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Antonie E EkkelenkampJos M J Paulusse
Feb 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aroa Duro-CastanoMaría J Vicent

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved