One pot synthesis of highly luminescent polyethylene glycol anchored carbon dots functionalized with a nuclear localization signal peptide for cell nucleus imaging

Nanoscale
Lei YangLi Yang

Abstract

Strong blue fluorescent polyethylene glycol (PEG) anchored carbon nitride dots (CDs@PEG) with a high quantum yield (QY) of 75.8% have been synthesized by a one step hydrothermal treatment. CDs with a diameter of ca. 6 nm are well dispersed in water and present a graphite-like structure. Photoluminescence (PL) studies reveal that CDs display excitation-dependent behavior and are stable under various test conditions. Based on the as-prepared CDs, we designed novel cell nucleus targeting imaging carbon dots functionalized with a nuclear localization signal (NLS) peptide. The favourable biocompatibilities of CDs and NLS modified CDs (NLS-CDs) are confirmed by in vitro cytotoxicity assays. Importantly, intracellular localization experiments in MCF7 and A549 cells demonstrate that NLS-CDs could be internalized in the nucleus and show blue light, which indicates that CDs may serve as cell nucleus imaging probes.

References

Dec 29, 2011·Journal of the American Chemical Society·Marta J KrysmannEmmanuel P Giannelis
Mar 17, 2012·Chemical Communications : Chem Comm·Pin-Che Hsu, Huan-Tsung Chang
Jul 19, 2012·Biomacromolecules·Eun Ji GohSei Kwang Hahn
Jun 14, 2013·Nanoscale Research Letters·Zhongcai GaoYuxia Wang
Mar 14, 2014·Chemistry : a European Journal·Jianhui DengShouzhuo Yao
Apr 5, 2014·ACS Applied Materials & Interfaces·Susanta Kumar BhuniaNikhil R Jana
May 24, 2014·Bioconjugate Chemistry·Shaobo RuanHuile Gao
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Jun 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhu Lian WuCheng Zhi Huang
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Moyun ChenXiaoping Wu

❮ Previous
Next ❯

Citations

Oct 2, 2015·ACS Applied Materials & Interfaces·Kai JiangHengwei Lin
Aug 12, 2015·ACS Applied Materials & Interfaces·Jia-Hui LiuYa-Ping Sun
Jun 9, 2015·Chemical Communications : Chem Comm·Abhishek GuptaChayan Kanti Nandi
Jun 5, 2016·Talanta·Li-Ming Shen, Jing Liu
Oct 30, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fatemeh Ostadhossein, Dipanjan Pan
Nov 3, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Quan-Xing MaoJian-Hua Wang
Nov 16, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ziwei SunHuihua Qu
Mar 21, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ayan PalArun Chattopadhyay
Feb 11, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haydar AliNikhil R Jana
Aug 18, 2018·Journal of Analytical Methods in Chemistry·Qianchun ZhangYuan Wang
Nov 27, 2018·Frontiers in Microbiology·Fengming LinZhan Chen
Sep 20, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Meiling ZhangHuihua Qu
Mar 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liping LiRuiping Zhang
Sep 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weijian LiuWeijun Wang
Aug 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Quan-Xing MaoJian-Hua Wang
Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao LiZhenhui Kang
Apr 10, 2019·Polymers·Konstantinos Dimos
Jan 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanan ZhangHaixia Wen
Jul 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·T SkaltsasN Tagmatarchis
Aug 22, 2018·Mikrochimica Acta·Fanyong YanXuguang Zhou
Oct 16, 2020·Nature Communications·Jiawen FangJacek K Stolarczyk
Jul 3, 2019·Advances in Colloid and Interface Science·Bin Bin ChenCheng Zhi Huang
Nov 26, 2020·International Journal of Nanomedicine·Yusheng ZhaoYan Zhao
Jun 3, 2021·International Journal of Molecular Sciences·Markéta HavrdováAthanasios B Bourlinos

❮ Previous
Next ❯

Related Concepts