One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles

Organic & Biomolecular Chemistry
Jiachen XiangAnxin Wu

Abstract

This paper described a decarboxylative deaminative dual-coupling reaction of amino acids with indoles to afford BIM scaffolds and its further application to the one-pot total synthesis of natural products. This method featured a stimulating example of activating amino acids in one pot as multi-carbon building blocks for transformation into final targets which are equipped with amino acid side chain backbones.

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Citations

Apr 11, 2017·Chemical Communications : Chem Comm·RahulKumar Rajmani Singh, Rai-Shung Liu
Jun 26, 2018·Organic & Biomolecular Chemistry·Yuanyuan WeiCongde Huo
Dec 13, 2017·The Journal of Organic Chemistry·Pedro Juan Llabres-CampanerBelén Abarca
May 3, 2018·Organic Letters·Ke-Si Du, Jing-Mei Huang

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