One risk assessment tool for cardiovascular disease, type 2 diabetes, and chronic kidney disease.

Diabetes Care
Marjan AlssemaJacqueline M Dekker

Abstract

Individuals at high risk for chronic cardiometabolic disease (cardiovascular disease [CVD], type 2 diabetes, and chronic kidney disease [CKD]) share many risk factors and would benefit from early intervention. We developed a nonlaboratory-based risk-assessment tool for identification of people at high cardiometabolic disease risk. Data of three population-based cohorts from different regions of the Netherlands were merged. Participants were 2,840 men and 3,940 women, white, aged 28-85 years, free from CVD, type 2 diabetes, and CKD diagnosis at baseline. The outcome was developing cardiometabolic disease during 7 years follow-up. Age, BMI, waist circumference, antihypertensive treatment, smoking, family history of myocardial infarction or stroke, and family history of diabetes were significant predictors, whereas former smoking, history of gestational diabetes, and use of lipid-lowering medication were not. The models showed acceptable calibration (Hosmer and Lemeshow statistics, P > 0.05) and discrimination (area under the receiver operating characteristic [ROC] curve 0.82 [95% CI 0.81-0.83] for women and 0.80 [0.78-0.82] for men). Discrimination of individual outcomes was lowest for diabetes (area under the ROC curve 0.70 for ...Continue Reading

References

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Citations

Nov 28, 2012·PLoS Medicine·Justin B Echouffo-Tcheugui, Andre P Kengne
Dec 15, 2015·Diabetes, Obesity & Metabolism·Mark WoodwardUNKNOWN ADVANCE Collaborative Group
Dec 10, 2016·International Journal of Clinical Practice·Karn WijarnpreechaWisit Cheungpasitporn
Jul 3, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Priya VartUte Bültmann
Nov 1, 2015·BMC Cardiovascular Disorders·Niels V van der HoevenBert-Jan H van den Born
Mar 29, 2018·Nutrition Reviews·Mattias Carlström, Susanna C Larsson

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Methods Mentioned

BETA
percutaneous
coronary artery bypass

Software Mentioned

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