PMID: 26833992DOI: 10.1002/adma.201506232Feb 3, 2016Paper
One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy
Advanced Materials
Yu ZhangChunhai Fan
Abstract
The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.
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