One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

Advanced Materials
Yu ZhangChunhai Fan

Abstract

The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.

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Citations

Dec 23, 2016·ACS Applied Materials & Interfaces·Yanhua LiBo Tang
Jan 21, 2017·ACS Applied Materials & Interfaces·Lian ZhuZhi-Ling Zhang
Jan 25, 2017·ACS Applied Materials & Interfaces·Min GaoZhuang Liu
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Nov 11, 2019·ACS Biomaterials Science & Engineering·Huijie ZhangJinghua Chen
Aug 24, 2017·ACS Applied Materials & Interfaces·Taoran TianYunfeng Lin
Aug 27, 2021·ACS Applied Materials & Interfaces·Peng GaoBo Tang

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