One Size Does Not Fit All: Marked Heterogeneity in Incidence of and Survival from Gastric Cancer among Asian American Subgroups.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Robert J HuangLatha S Palaniappan

Abstract

Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns. We utilized data from 13 regional United States cancer registries from 1990 to 2014 to determine secular trends in incidence and survivorship from NCGC. Data were analyzed for NHWs and the six largest Asian American subgroups: Chinese, Japanese, Filipino, Korean, Vietnamese, and South Asian (Indian/Pakistani). There exists substantial heterogeneity in NCGC incidence between Asian subgroups, with Koreans (48.6 per 100,000 person-years) having seven-fold higher age-adjusted incidence than South Asians (7.4 per 100,000 person-years). Asians had generally earlier stages of diagnosis and higher rates of surgical resection compared with NHWs. All Asian subgroups also demonstrated higher 5-year observed survival compared with NHWs, with Koreans (41.3%) and South Asians (42.8%) having survival double that of NHWs (20.1%, P < 0.001). In multivariable regression, differences in stage of diagnosis and rates of ...Continue Reading

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Citations

May 27, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Claudia SantucciCarlo La Vecchia
Jul 31, 2020·Therapeutic Advances in Gastroenterology·Andrew CanakisShailja C Shah
Aug 3, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Claudia SantucciCarlo La Vecchia
Feb 3, 2021·International Journal of Cancer. Journal International Du Cancer·Robert J HuangLatha P Palaniappan
Jul 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shailja C ShahMonica Saumoy
Jun 1, 2021·Gastrointestinal Endoscopy Clinics of North America·Robert J Huang, Joo Ha Hwang
Jul 16, 2021·Journal of Surgical Oncology·John D KaralisSam C Wang
Aug 20, 2021·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss

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