One-stage human acellular nerve allograft reconstruction for digital nerve defects

Neural Regeneration Research
Xue-Yuan LiHong Chen

Abstract

Human acellular nerve allografts have a wide range of donor origin and can effectively avoid nerve injury in the donor area. Very little is known about one-stage reconstruction of digital nerve defects. The present study observed the feasibility and effectiveness of human acellular nerve allograft in the reconstruction of < 5-cm digital nerve defects within 6 hours after injury. A total of 15 cases of nerve injury, combined with nerve defects in 18 digits from the Department of Emergency were enrolled in this study. After debridement, digital nerves were reconstructed using human acellular nerve allografts. The patients were followed up for 6-24 months after reconstruction. Mackinnon-Dellon static two-point discrimination results showed excellent and good rates of 89%. Semmes-Weinstein monofilament test demonstrated that light touch was normal, with an obvious improvement rate of 78%. These findings confirmed that human acellular nerve allograft for one-stage reconstruction of digital nerve defect after hand injury is feasible, which provides a novel trend for peripheral nerve reconstruction.

References

Oct 1, 1992·Plastic and Reconstructive Surgery·S E Mackinnon, A R Hudson
Jan 1, 1987·The Journal of Hand Surgery·J Bell-Krotoski, E Tomancik
Feb 2, 2002·Journal of Reconstructive Microsurgery·M F Meek, J H Coert
Dec 14, 2004·Tissue Engineering·Terry W HudsonChristine E Schmidt
Feb 3, 2005·Tissue Engineering·Terry W HudsonChristine E Schmidt
Jan 15, 2008·Journal of Reconstructive Microsurgery·Maria Siemionow, Erhan Sonmez
Mar 18, 2009·Muscle & Nerve·Elizabeth L WhitlockGregory H Borschel
Nov 6, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Li-Min YangLi Jiang
Jun 11, 2011·Muscle & Nerve·Amy M MoorePhilip J Johnson
Jan 25, 2012·Annals of Plastic Surgery·Ivica DucicMatthew L Iorio
Oct 30, 2012·The Journal of Hand Surgery·Mickey S ChoGregory M Buncke
Jun 12, 2013·Journal of Neurosurgery·Yerko A BerrocalAllan D Levi
Sep 4, 2013·The Journal of Hand Surgery·John S TarasLucy A McCabe
Feb 27, 2014·Hand : Official Journal of the American Association for Hand Surgery·Anthony OwusuJonathan Isaacs
May 9, 2014·The International Journal of Artificial Organs·Bill G X ZhangPeter F M Choong
May 20, 2014·Hand : Official Journal of the American Association for Hand Surgery·Jonathan Isaacs, Timothy Browne

❮ Previous
Next ❯

Citations

Apr 21, 2016·Hand Clinics·Bauback Safa, Gregory Buncke
Mar 24, 2018·Biofabrication·Eugen B PetcuPaul D Dalton
Dec 17, 2019·Plastic and Reconstructive Surgery·Jonathan I LeckenbyEsther Vögelin
Jan 28, 2020·Plastic and Reconstructive Surgery·Jonathan I LeckenbyEsther Vögelin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved