Abstract
Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) based on supported liquid membrane (SLM) with large surface area, excellent structural stability, prominent biocompatibility, and acid degradability. The products were characterized by transmission electron micrograph, X-ray diffraction, Fourier transform infrared spectra, UV-vis spectroscopy, zeta potential, and particle size distribution. The results showed that the tube-like structure facilitated podophyllotoxin (PPT) diffusion into the cavity of hollow structure, and the drug loading and encapsulation efficiency of CCNTs for PPT are as high as 38.5 and 64.4 wt.%, respectively. In vitro drug release study showed that PPT was released from the CCNTs in a pH-controlled and time-dependent manner. The treatment of HEK 293T and SGC 7901 cells demonstrated that PPT-loaded CCNTs were less toxic to normal cells and more effective in antitumor potency compared with free drugs. In addition, PPT-loaded CCNTs also enhanced the...Continue Reading
References
Jan 1, 1979·Cancer Chemotherapy and Pharmacology·A M Arnold
May 1, 1989·Pharmaceutical Research·J C ShahD Chow
Dec 7, 1988·Journal of the National Cancer Institute·J M van MaanenH M Pinedo
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Feb 1, 1997·Nature Medicine·G HelmlingerR K Jain
Nov 6, 1998·Science·F CarusoH Mohwald
Dec 5, 2000·Current Pharmaceutical Design·M GordalizaA S Feliciano
Aug 2, 2002·Life Sciences·Xuan TianWen-Guang Li
Feb 18, 2004·Biomaterials·Jin-Ho ChoyOk-Jin Han
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Mar 22, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Niklas LogesWolfgang Tremel
Jan 30, 2007·Biomaterials·Mi-Kyung LeeChong-Kook Kim
Oct 6, 2007·Biological Trace Element Research·Catherine AuMichael Aschner
Feb 1, 2008·Toxicology and Applied Pharmacology·Joan E RobertsColin F Chignell
Jun 17, 2008·Journal of Colloid and Interface Science·Zhaodong NanWanguo Hou
Nov 5, 2008·Journal of the American Chemical Society·Wei WeiZhe-Yu Shen
May 7, 2009·Nanotechnology·R R ZhuS D Yao
Sep 4, 2009·Biological Trace Element Research·Ye-Zhong ZhangYi Liu
Oct 6, 2009·Toxicology and Applied Pharmacology·Albert R WielgusJoan E Roberts
Oct 27, 2009·Biomaterials·Ang LiShilong Wang
Jan 5, 2010·International Journal of Pharmaceutics·Lili QinXiaoyu Sun
Jan 21, 2010·Biological Trace Element Research·Mostafa Khajeh
Sep 3, 2010·Biological Trace Element Research·Barbara DolinskaFlorian Ryszka
Sep 3, 2010·Biological Trace Element Research·Wen-Rui WangShi-Long Wang
Oct 12, 2010·Biomaterials·Ang LiShilong Wang
Feb 3, 2011·ACS Nano·Bin LuoChang-Chun Wang
Feb 18, 2011·Angewandte Chemie·Biao KongGuoyue Shi