One-Step Curable, Covalently Immobilized Coating for Clinically Relevant Surfaces That Can Kill Bacteria, Fungi, and Influenza Virus.

ACS Applied Materials & Interfaces
Sreyan GhoshJayanta Haldar

Abstract

Microbial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections. Cationic polymeric coatings have gained enormous attention to tackle this scenario. However, non-biodegradable cationic polymer coated surfaces suffer from accumulation of microbial debris leading to toxicity and consequent complexities. Synthetic reproducibility and sophisticated coating techniques further limit their application. In this present study, we have developed one-step curable, covalent coatings based on two organo- and water-soluble small molecules, quaternary benzophenone-based ester and quaternary benzophenone-based amide, which can cross-link on surfaces upon UV irradiation. Upon contact, the coating completely killed bacteria and fungi in vitro including drug-resistant pathogens methicillin-resistant Staphylococcus aureus (MRSA) and fluconazole-resistant Candida albicans spp. The coating also showed antiviral activity against notorious influenza virus with 100% killing. The coated surfaces also killed stationary-phase cells of MRSA, which cannot be eradicated by traditional antibiotics. Upon hydrolysis, the surfaces switched to an antifouling state display...Continue Reading

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Citations

Mar 9, 2021·Bioconjugate Chemistry·Caihong LinYong-Guang Jia
Feb 19, 2021·APL Bioengineering·Sushma Kumari, Kaushik Chatterjee
May 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mohd Abubakar SadiqueRaju Khan
Jun 2, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Shipra Bhatt, Debjani Bagchi
Jul 15, 2021·Chemical Society Reviews·Nan WangTetsuro Majima

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