One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis

Nanoscale
Junjun LiuBai Yang

Abstract

Carbon dots (CDs) with high quantum yield (QY), low toxicity and good biocompatibility are the major quests of biomedical research. In this paper, we develop a green, simple hydrothermal approach to synthesize water-soluble, nontoxic, highly photoluminescent carbon nanodots (CNDs) from Metronidazole, which possess selective antibacterial activity against obligate anaerobes for the first time. Metronidazole was used as a sole precursor to prepare CNDs at 250 °C (CNDs-250) for 8 h. After the CNDs-250 with an average size of 2.9 nm, consisting of a highly carbon crystalline core and various surface groups were obtained, the formation and fluorescence mechanisms of CNDs were further explored by adjusting the reaction time and reaction temperatures, respectively. Biological experimental data proved that CNDs-250 can only inhibit the growth of obligate anaerobes, such as Porphyromonas gingivalis (P. gingivalis) directly, instead of further functionalization. Besides, CNDs-250 with a QY around 28.1% exhibit an obvious excitation-dependent emission, which will be conducive to multicolor bioimaging. And it may not only develop a new approach for researchers to prepare multifunctional CDs, but also provide a valuable strategy for the the...Continue Reading

References

Apr 1, 1977·Scottish Medical Journal·A T Willis
Dec 1, 1975·The Journal of Antimicrobial Chemotherapy·H R InghamJ H Hale
Oct 8, 2004·Journal of the American Chemical Society·Xiaoyou XuWalter A Scrivens
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna PopadiakAnna M Blom
Apr 19, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Zhisong LuXu Yang
Oct 24, 2008·Advances in Colloid and Interface Science·Virender K SharmaYekaterina Lin
Nov 17, 2009·Journal of Nanoscience and Nanotechnology·Prachi JoshiVinay Guptas
Jan 30, 2010·Expert Review of Vaccines·Rosa A M Jong, Wil A van der Reijden
Mar 11, 2010·Advanced Materials·Goki EdaManish Chhowalla
May 8, 2010·Chemical Communications : Chem Comm·Hui ZhuXiurong Yang
Nov 15, 2011·Chemical Communications : Chem Comm·Amit JaiswalArun Chattopadhyay
Apr 26, 2012·FEMS Microbiology Letters·Nagihan Bostanci, Georgios N Belibasakis
May 30, 2014·ACS Nano·Hanjun SunXiaogang Qu
Oct 10, 2014·Nanoscale·Hui DingHuan-Ming Xiong
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Nov 14, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Jayasmita JanaTarasankar Pal
Nov 28, 2015·Journal of Innate Immunity·Małgorzata BenedykJan Potempa
Apr 12, 2016·ACS Applied Materials & Interfaces·Mohammed Jaouad MezianiYa-Ping Sun
Oct 28, 2016·ACS Applied Materials & Interfaces·Jingjing YangFu-Gen Wu

❮ Previous
Next ❯

Citations

Nov 16, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ziwei SunHuihua Qu
Jan 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yusheng ZhaoHuihua Qu
Dec 17, 2019·Current Pharmaceutical Design·Anisha AnandChih-Ching Huang
Mar 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huibo WangZhenhui Kang
Aug 15, 2020·Expert Review of Anti-infective Therapy·Mehran AlaviEsmaiel Jabbari
Feb 13, 2018·Nanoscale·Junchao LiuLei Jiang
Sep 20, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Meiling ZhangHuihua Qu
Aug 18, 2020·International Journal of Nanomedicine·Gaofeng LiangShegan Gao
Sep 16, 2020·Materials·Rachael Knoblauch, Chris D Geddes
Mar 22, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Titto Sunil JohnSyed Hadi Hasan
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peiwei GongZhe Liu
Mar 31, 2019·Colloids and Surfaces. B, Biointerfaces·Yu HanJianguo Liu
May 29, 2019·Journal of Colloid and Interface Science·Sara Madadi ArdekaniVincent G Gomes
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xi-Le HuDaijie Chen
May 29, 2021·RSC Medicinal Chemistry·Nuno ValeJoaquim C G Esteves da Silva
Jun 25, 2021·Nature Communications·Z L ShawSumeet Walia
Jun 12, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Mingxi YangBai Yang
Nov 23, 2017·ACS Applied Materials & Interfaces·Tanglue FengBai Yang
Dec 31, 2020·ACS Central Science·Junjun LiuBai Yang
Jul 10, 2019·ACS Applied Materials & Interfaces·Zhaohua MiaoZhengbao Zha
Sep 22, 2017·ACS Infectious Diseases·Scott G HarrounHan-Jia Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.