One-step osteochondral repair with cartilage fragments in a composite scaffold.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
A MarmottiG M Peretti

Abstract

This study proposes a single-step therapeutic approach for osteochondral defects using autologous cartilage fragments loaded onto a scaffold composed of a hyaluronic acid (HA) derivative, human fibrin glue (FG) and autologous platelet-rich-plasma (PRP), in a rabbit model. The aim is to demonstrate the in vitro outgrowth of chondrocytes from cartilage fragments and the in vivo formation of a functional repair tissue. In vitro: minced articular cartilage was loaded onto two different types of scaffold (paste or membrane) according to two different HA preparations (injectable HA-derivative or HA-derivative felt). In vivo: trochlear osteochondral defects were created in 50 adult rabbits, which were then assigned to 5 different treatment groups: cartilage fragments loaded onto membrane scaffolds with FG (Group 1) or without FG (Group 2); membrane scaffolds alone with FG (Group 3) or without FG (Group 4); empty defects (Group 5). Membrane scaffolds were used "in vivo" for simpler preparation and better adhesive properties. Repair processes were evaluated histologically and by immunohistochemistry at 1, 3, and 6 months. An in vitro time-dependent cell outgrowth from cartilage fragments was observed with both types of scaffolds. At 6 m...Continue Reading

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Citations

Nov 13, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A MarmottiG M Peretti
Jan 11, 2013·Science Translational Medicine·Blanka SharmaJennifer H Elisseeff
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Apr 16, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Davide Edoardo BonasiaAnnunziato Amendola
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