One-step preparation of chitosan-coated cationic liposomes by an improved supercritical reverse-phase evaporation method

Langmuir : the ACS Journal of Surfaces and Colloids
Katsuto OtakeMasahiko Abe

Abstract

High-pressure carbon dioxide in contact with water dissolves to form carbonic acid, causing a decrease in pH. By use of these characteristics of a CO2/H2O biphasic system, chitosan-coated cationic liposomes of l-alpha-dipalmitoylphosphatidylcholine were successfully prepared by an improved supercritical reverse-phase evaporation (ISCRPE) method. Liposome-chitosan complexes carrying a positive charge were prepared in a single-step procedure without the use of acid or organic solvent, including ethanol. The maximum trapping efficiency of liposomes prepared by the ISCRPE method was 17%, with or without the addition of chitosan, compared to only 2% for liposomes prepared by the Bangham method. Furthermore, the liposomal dispersion was stable at room temperature in a sealed tube for over 30 days.

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Citations

Jul 4, 2008·AAPS PharmSciTech·Louise A MeureFariba Dehghani
Dec 29, 2015·International Journal of Pharmaceutics·Philip W LabuschagneLonji Kalombo
Jul 4, 2008·International Journal of Pharmaceutics·Irene Pasquali, Ruggero Bettini
Nov 27, 2007·International Journal of Pharmaceutics·Aranya ManosroiJiradej Manosroi
Mar 9, 2012·Journal of Liposome Research·Shashidhar M GhatnurUdaya Sankar Kadimi
Sep 17, 2013·Nanoscale Research Letters·Islane Espírito SantoElaine Cabral-Albuquerque
Nov 21, 2007·Journal of Liposome Research·Liliam Becherán MarónMaria Helena Bueno da Costa
Sep 29, 2019·Journal of Liposome Research·C Has, P Sunthar
May 22, 2019·Current Pharmaceutical Design·Anilkumar T SJyh-Ping Chen
Mar 28, 2008·Biomacromolecules·Fariba DehghaniFeng H Tay
Dec 17, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Louise A MeureFariba Dehghani
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Yuuka Fukui, Keiji Fujimoto
Nov 28, 2020·Current Topics in Medicinal Chemistry·Chun ChanXiaolin Cheng

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