One-step preparation of chitosan solid nanoparticles by electrospray deposition

International Journal of Pharmaceutics
Shaoling Zhang, Kohsaku Kawakami

Abstract

Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors affecting electrospray behavior, i.e., stable electrospray was achieved only when viscosity was high and/or conductivity was low. Smaller particles could be obtained by decreasing acetic acid concentration, chitosan concentration, and/or flow rate. Furthermore, addition of ethanol could effectively stabilize the electrospray by decreasing the solution conductivity and increasing the solution viscosity. By optimizing the solution and operation parameters, the average diameter of the chitosan particles was reduced down to 124 nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems.

References

Dec 25, 1996·Journal of Colloid and Interface Science·K Tang, A Gomez
Apr 15, 2003·Inhalation Toxicology·Christopher C DaigleMark W Frampton
Oct 20, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil A AgnihotriTejraj M Aminabhavi
Apr 30, 2005·Biomaterials·Xinying GengJinho Jang
Jul 18, 2006·Journal of Colloid and Interface Science·Jingwei XieChi-Hwa Wang
Aug 5, 2006·International Journal of Pharmaceutics·Jessica Elversson, Anna Millqvist-Fureby
Nov 10, 2006·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Nov 17, 2006·The Journal of Physical Chemistry. B·Ivo B RietveldKazumi Matsushige
Dec 30, 2006·Nature Reviews. Drug Discovery·John S Patton, Peter R Byron
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Catarina Pinto ReisFrancisco Veiga
Jul 3, 2007·Advanced Drug Delivery Reviews·Filippos KesisoglouYunhui Wu
Nov 13, 2007·Trends in Biotechnology·Jean C SungDavid A Edwards
Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Mar 25, 2008·International Journal of Pharmaceutics·Wei YangRobert O Williams
Aug 30, 2008·International Journal of Pharmaceutics·Bernard Van EerdenbrughPatrick Augustijns
Dec 25, 2008·Pharmaceutical Research·Christine Vauthier, Kawthar Bouchemal
Jul 2, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dong Wook LeeKuen Yong Lee
Feb 23, 2010·International Journal of Pharmaceutics·Kohsaku KawakamiKatsuhide Terada

❮ Previous
Next ❯

Citations

Dec 24, 2013·Colloids and Surfaces. B, Biointerfaces·Lihua CaoHongliang Jiang
Sep 18, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mullika KongsongNongnuj Muangsin
Jul 26, 2014·International Journal of Nanomedicine·Luiza A FrankSilvia S Guterres
Jul 23, 2013·Journal of Drug Targeting·Hairui LiLifeng Kang
May 16, 2012·International Journal of Pharmaceutics·Kohsaku Kawakami
Jun 28, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jianing MengBi-Botti C Youan
May 4, 2011·International Journal of Pharmaceutics·M A Tavares CardosoJ R van Ommen
Sep 30, 2015·Advanced Drug Delivery Reviews·Praveena JayaramanDinesh Kumar Srinivasan
Mar 21, 2013·Biomatter·Radhakrishnan Sridhar, Seeram Ramakrishna
Dec 5, 2013·Carbohydrate Polymers·Rocío Pérez-MasiáAmparo López-Rubio
Apr 3, 2013·Carbohydrate Polymers·Yuancai DongReginald B H Tan
Jun 12, 2016·Journal of Pharmaceutical Sciences·Duong Nhat NguyenGuy Van den Mooter
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wing-Fu Lai, Zhen-Dan He
Mar 10, 2017·Drug Development and Industrial Pharmacy·Hoang Nhan HoJyrki Heinämäki
Jun 14, 2017·Critical Reviews in Food Science and Nutrition·Ali AlehosseiniNick Tucker
Jul 1, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Sruthi SreekumarJose M Lagaron
Jul 14, 2018·Biomedical Materials·Esra Cansever MutluArzu Demir
Feb 11, 2014·Macromolecular Rapid Communications·Sheyda LabbafMohan Edirisinghe
May 3, 2014·Chemical & Pharmaceutical Bulletin·Usharani NagarajanBalachandran Unni Nair
Sep 26, 2019·Journal of Food Science·Francisco Rodríguez-FélixJosé Agustín Tapia-Hernández
Oct 13, 2019·Current Medicinal Chemistry·Laura G Gómez-Mascaraque, Amparo Lopez-Rubio
Nov 6, 2018·Micromachines·Xiang WangGaofeng Zheng
May 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qingchang ChenXiaoli Zhao
Jun 10, 2011·The Analyst·Samuel ChigomeNelson Torto
Aug 26, 2020·Electrophoresis·Anna TycovaFrantisek Foret
May 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Muhammad GulfamBong Geun Chung
May 6, 2015·Journal of Agricultural and Food Chemistry·José A Tapia-HernándezFrancisco Rodríguez-Félix
Mar 15, 2011·Molecular Pharmaceutics·Shaoling ZhangShinji Sakuma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advanced Drug Delivery Reviews
Mehrdad HamidiPedram Rafiei
Journal of Controlled Release : Official Journal of the Controlled Release Society
Sunil A AgnihotriTejraj M Aminabhavi
© 2021 Meta ULC. All rights reserved