One-Step Synthesis of Sulfonamides from N-Tosylhydrazones

Organic Letters
Andy S TsaiVincent Mascitti

Abstract

The first described reaction between N-tosylhydrazone and SO2 is reported to provide alkyl sulfonamides in the presence of various amines. In this procedurally simple method, hydrazones of both unsaturated aldehydes and ketones proceed in moderate to excellent yields. Primary and secondary aliphatic amines are accommodated in this reaction, which provides a novel route to sulfonamides.

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Citations

May 23, 2017·Organic & Biomolecular Chemistry·Minghui ZhuHua Wang
Dec 3, 2016·Chemistry : a European Journal·Yuanchao XiangJie Wu
Mar 24, 2016·Chemical Communications : Chem Comm·Guojiao WuJianbo Wang
Nov 8, 2017·Chemical Communications : Chem Comm·Hongguang XiaJie Wu
Jul 5, 2016·Organic & Biomolecular Chemistry·Jian-Bo Feng, Xiao-Feng Wu
Oct 24, 2018·Chemical Communications : Chem Comm·Guanyinsheng QiuJie Wu
Feb 1, 2019·Chemical Communications : Chem Comm·Shengqing YeGuanyinsheng Qiu

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