One-two punch injury to tolerance mechanisms in graft-versus-host disease.

The Journal of Clinical Investigation
Léolène J Carrington, Ivan Maillard

Abstract

Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation that resembles autoimmunity, with unclear pathogenesis and few effective therapeutic options. In this issue of the JCI, Dertschnig et al. used mouse models to investigate the basis of T cell autoreactivity following GVHD. Notably, GVHD caused irreversible damage to a population of tolerogenic stromal cells that display peripheral tissue-restricted antigens in lymph nodes, which impaired their capacity to purge and suppress autoreactive T cells. Together with damage to central tolerance mechanisms in the thymus, these findings outline a critical one-two punch injury that profoundly disrupts immune tolerance in this devastating disease.

References

Mar 5, 2005·Blood·Elizabeth TivolWilliam R Drobyski
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi ZhangStephen G Emerson
Sep 26, 2007·Nature Immunology·Alexander LinkSanjiv A Luther
Dec 4, 2009·The Journal of Clinical Investigation·Il-Kang NaMarcel R M van den Brink
Mar 24, 2010·The Journal of Experimental Medicine·Jarish N CohenVictor H Engelhard
Nov 24, 2011·PloS One·Omar KhanMatthew F Krummel
May 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao WuDefu Zeng
Aug 26, 2014·Nature Immunology·Viviana CremascoShannon J Turley
Nov 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumiko SuenagaKouji Matsushima
Mar 21, 2017·The Journal of Clinical Investigation·Jooho ChungIvan Maillard
Jan 25, 2019·Blood·Stefanie SarantopoulosKeith M Sullivan
Mar 9, 2019·Human Immunology·William McManigleStefanie Sarantopoulos
Jan 10, 2020·The Journal of Clinical Investigation·Simone DertschnigRonjon Chakraverty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved