Abstract
To test the efficacy of omeprazole, furazolidone and amoxicillin triple therapy for the treatment of Helicobacter pylori infection after failure of standard first-line therapy recommended by the Asia-Pacific Consensus on the management of H. pylori infection. Patients with failed H. pylori eradication received omeprazole, 20 mg, furazolidone, 100 mg, and amoxicillin, 1 g, all twice daily for 1 week. Endoscopy (CLO test, histology and culture) was performed before treatment. Post-treatment H. pylori status was determined by 13C-urea breath test 6 weeks later. Fifty patients were recruited. Resistance to metronidazole, clarithromycin and both drugs was in the range of 50-64%, 60-75% and 40-50%, respectively, after failure of first-line therapy. Amoxicillin resistance was not found. The intention-to-treat and per protocol H. pylori eradication rates were 52% and 53%, respectively. Patients with double resistance to metronidazole and clarithromycin showed the lowest eradication rate (38%), which was significantly lower than that of patients with sensitive strains (88%). Side-effects were minimal and compliance was excellent (98%). One-week omeprazole, furazolidone and amoxicillin rescue therapy achieved a high eradication rate in s...Continue Reading
References
May 26, 1990·Lancet·E A Rauws, G N Tytgat
Sep 1, 1990·Antimicrobial Agents and Chemotherapy·C E HaasJ J Schentag
Dec 24, 1988·Lancet·B J MarshallC R Sanderson
Apr 1, 1996·Gastroenterology·R J HopkinsE A Turney
May 1, 1996·Gut·C K ChingC L Lai
Oct 1, 1996·Gastroenterology·L Chen, R J Groszmann
Nov 19, 1997·Digestive Diseases and Sciences·M J BuckleyC A O'Morain
Sep 16, 1998·Journal of Gastroenterology and Hepatology·S K Lam, N J Talley
Jan 29, 1999·Gastroenterology·T LindC Cederberg
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·B C WongC L Lai
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·S D XiaoG N Tytgat
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·W Z LiuG N Tytgat
Apr 24, 1999·Alimentary Pharmacology & Therapeutics·J M LeeC A O'Morain
Sep 30, 1999·European Journal of Gastroenterology & Hepatology·J P GisbertA García Plaza
Oct 30, 1999·Alimentary Pharmacology & Therapeutics·J P GisbertJ M Pajares
Oct 30, 1999·Antimicrobial Agents and Chemotherapy·F MégraudC F Burman
Dec 22, 1999·Helicobacter·F GomollónM Montoro
Jan 29, 2000·Alimentary Pharmacology & Therapeutics·D Y GrahamH M El-Zimaity
Feb 15, 2000·Gut·L J van DoornW A de Boer
Mar 29, 2000·Alimentary Pharmacology & Therapeutics·R MalekzadehS Massarrat
Jul 25, 2000·Alimentary Pharmacology & Therapeutics·W H WangS K Lam
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·W M WongS K Lam
Nov 9, 2000·Alimentary Pharmacology & Therapeutics·W Z LiuG N Tytgat
Jan 3, 2001·Alimentary Pharmacology & Therapeutics·S D XiaoN N Cheng
Feb 24, 2001·Journal of Gastroenterology and Hepatology·N Leung
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·B C WongS K Lam
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·H FakheriS Massarrat
Mar 17, 2001·The Journal of Antimicrobial Chemotherapy·F BarchiesiM A Viviani
May 1, 2001·Alimentary Pharmacology & Therapeutics·J TankovicJ C Delchier
Citations
Feb 25, 2005·Current Infectious Disease Reports·Francis Mégraud
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F ParenteG Bianchi Porro
Aug 29, 2002·Helicobacter·Franco BazzoliTheodore Rokkas
Jan 13, 2005·Alimentary Pharmacology & Therapeutics·Asghar QasimColm O'Morain
Jan 13, 2005·Alimentary Pharmacology & Therapeutics·W M WongB C-Y Wong
Sep 12, 2007·Journal of Gastroenterology and Hepatology·György M Buzás, Jolán Józan
Nov 18, 2004·Annals of Clinical Microbiology and Antimicrobials·Raul V DesturaRichard L Guerrant
Aug 27, 2004·Drugs·Francis Mégraud
Nov 6, 2008·World Journal of Gastroenterology : WJG·Guilherme-Eduardo-Goncalves FelgaJaime-Natan Eisig
Feb 21, 2009·World Journal of Gastroenterology : WJG·Hong Cheng, Fu-Lian Hu
Jan 18, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Angelo ZulloVincenzo De Francesco
Nov 26, 2005·Expert Review of Anti-infective Therapy·Ala I Sharara
May 9, 2008·Expert Opinion on Drug Safety·Avelyn KwokRupert Wl Leong
Feb 21, 2007·Helicobacter·Alexander A NijevitchAlexander G Arsamastsev
Aug 5, 2003·Alimentary Pharmacology & Therapeutics·C-H ChiJ-J Wu
May 20, 2003·Alimentary Pharmacology & Therapeutics·E GenéJ P Gisbert
Dec 23, 2003·Alimentary Pharmacology & Therapeutics·H FakheriR Malekzadeh
Oct 30, 2008·Journal of Digestive Diseases·Fu Lian HuYong Xie
Aug 3, 2006·Helicobacter·Ala I ShararaSouha S Kanj
Sep 12, 2006·Helicobacter·Yi-Chia LeeJaw-Town Lin
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Hamed DaghaghzadehMostafa Raeisi
Aug 21, 2002·Expert Opinion on Pharmacotherapy·Harry Hua-Xiang XiaShiu Kum Lam
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Nov 16, 2010·Helicobacter·Saghi RiahizadehSadegh Massarrat
Apr 17, 2019·Helicobacter·Mireia BaylinaIgnasi Puig
Nov 18, 2003·Helicobacter·Francesco PerriColm O'Morain
Mar 29, 2011·Hospital Practice·Jay LutherRichard J Saad