PMID: 9421124Jan 8, 1998Paper

One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit?

Helicobacter
H J O'ConnorK Cunnane

Abstract

Clarithromycin, a new acid stable macrolide antibiotic with proven efficacy against Helicobacter pylori, has been widely incorporated into eradication regimens but its optimal dosage schedule remains controversial. The standard dose of clarithromycin is 250 mg twice daily. In a prospective study designed to evaluate the helicobactericidal efficacy, patient acceptability, and ulcer healing efficacy of a triple therapy regimen incorporating high dose clarithromycin, 100 consecutive patients with H. pylori-positive peptic ulcer received omeprazole 20 mg twice daily in combination with metronidazole 400 mg twice daily and clarithromycin 500 mg twice daily for seven days. H. pylori status was assessed before and at least 4 weeks after therapy by rapid urease test and histology. Adverse events and compliance were assessed by direct questioning. Only two patients failed to attend for repeat endoscopy, leaving 98 evaluable patients. Of these, 94 were H. pylori-negative after therapy, giving an intention-to-treat eradication rate of 94% (95% confidence interval, 89%-99%). The ulcer healing rate was 92% (86%-98%), and ulcer healing was significantly associated with H. pylori eradication (p < 0.01). Adverse events were reported by 33% of ...Continue Reading

References

Jul 1, 1992·Postgraduate Medical Journal·H J O'Connor
May 1, 1995·Scandinavian Journal of Gastroenterology·W A de Boer, G N Tytgat
Feb 1, 1995·Postgraduate Medical Journal·H J O'ConnorK Cunnane
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·H J O'Connor
Feb 1, 1996·Antimicrobial Agents and Chemotherapy·J VersalovicM F Go

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Citations

Jul 7, 2001·Irish Journal of Medical Science·H J O'ConnorB Flynn
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·G A PipkinJ R Wood
Aug 19, 2006·Expert Opinion on Investigational Drugs·Andrea MorgnerStephan Miehlke

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