One year clinical and six month angiographic results of drug eluting stents for ST elevation acute myocardial infarction: 'real world' comparison between sirolimus- and paclitaxel-eluting stents

International Journal of Cardiology
Kyung Woo ParkWoo-Young Chung

Abstract

Concerns about safety of drug eluting stents have stirred up controversy on their use in patients with acute STEMI. It is also unknown whether differences in efficacy and safety exist between sirolimus- (SES) and paclitaxel-eluting stents (PES). To investigate the difference in angiographic results and clinical outcome between SES and PES in the treatment of acute STEMI, we analyzed "real world" 6 months angiographic and 1 year clinical outcome of 244 patients, comparing the results between SES and PES. 244 consecutive acute STEMI patients were analyzed retrospectively (185 patients in SES group (Group S), 59 patients in PES group (Group P). Immediate post PCI and six month angiographic findings were analyzed by quantitative coronary angiography. Clinical events up to 1 year including cardiovascular death, myocardial infarction, and target lesion revascularization were also analyzed. Baseline clinical and immediate post-procedure angiographic characteristics were similar in the two groups except for mean stent diameter and length which was slightly wider and shorter in group P compared with group S (Mean stent diameterxlength: 3.12+/-0.34x24.4+/-5.1 vs. 3.01+/-0.34x26.6+/-7.2 mm in group P vs. S, p=0.02, p=0.03). At six months,...Continue Reading

References

Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Aug 18, 2005·The New England Journal of Medicine·Stephan WindeckerBernhard Meier
Sep 15, 2006·The New England Journal of Medicine·Christian SpauldingUNKNOWN TYPHOON Investigators
Sep 15, 2006·The New England Journal of Medicine·Gerrit J LaarmanMark Patterson
Feb 14, 2007·The New England Journal of Medicine·Laura MauriDonald E Cutlip
Feb 14, 2007·The New England Journal of Medicine·Christian SpauldingPatrick W Serruys
Apr 25, 2007·American Heart Journal·Vincenzo PasceriGermano Di Sciascio
Jun 19, 2007·Journal of the American College of Cardiology·Piergiovanni BuonamiciDavid Antoniucci

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