One-year clinical outcomes of dialysis patients after implantation with sirolimus-eluting coronary stents

Circulation Journal : Official Journal of the Japanese Circulation Society
Takenori OkadaNobuoki Kohno

Abstract

The efficacy of sirolimus-eluting stents (SESs) has not been established in dialysis patients. This study was a non-randomized observational single-center registry in a community hospital: data for 80 consecutive dialysis patients who underwent percutaneous coronary intervention (PCI) with SES were compared with those of a historical group of consecutive 124 dialysis patients treated with bare-metal stents (BMS). After 1 year, the cumulative incidence of major adverse cardiac events (MACE), comprising cardiac death, nonfatal myocardial infarction, stent thrombosis, or target lesion revascularization (TLR), was 25.2% in the SES group and 38.2% in the BMS group (p=0.048). In multivariate analysis, use of SES remained an independent predictor of MACE at 1 year after PCI (risk ratio 0.70, 95% confidence interval 0.52-0.93, p=0.015). Rates of TLR were 21.7% in the SES group and 30.9% in the BMS group and (p=0.15). Subgroup analysis showed that use of SES was effective in patients with small vessels, non-diabetic patients, and patients without highly calcified lesions. In dialysis patients, the implantation of SES was moderately effective in reducing MACE at 1 year after PCI as compared with BMS. However, the TLR rate at 1 year was r...Continue Reading

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Citations

Jan 1, 2010·Cardiovascular Intervention and Therapeutics·Shuichi OshimaKenichiro Higa
Oct 12, 2012·Cardiovascular Intervention and Therapeutics·Hiroaki TsujitaYouichi Kobayashi
Jan 27, 2011·Heart and Vessels·Michiaki HigashitaniNobuhisa Hagiwara
Apr 10, 2010·International Heart Journal·Eiji IchimotoIssei Komuro
Jan 6, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Masaya OtsukaYasuhiko Hayashi
Sep 15, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiromichi TamekiyoYasuki Kihara
Oct 20, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hajime FujimotoHiroyoshi Yokoi
Dec 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi SakakibaraToyoaki Murohara
Jan 17, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Chikaaki MotodaYasuki Kihara
Jun 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zhi Jian WangYu Jie Zhou
May 28, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ahmed Abdel-LatifKhaled M Ziada
Mar 26, 2016·Journal of the American College of Cardiology·Tara I ChangWolfgang C Winkelmayer
Jun 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lisa KitasatoJunya Ako
Mar 9, 2018·Annals of Vascular Diseases·Jiro Aoki, Yuji Ikari
Mar 29, 2019·Journal of Cardiovascular Medicine·Vincenzo Alessandro GaliffaCatherine Klersy
Jun 2, 2012·Expert Review of Cardiovascular Therapy·Michael Donahue, Carlo Briguori
Dec 28, 2012·The Korean Journal of Internal Medicine·Chul Soo Park

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