One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation.

Resuscitation
Kathleen L MeertTherapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss

Abstract

To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II ≥70) were included in this analysis. One-year follow-up was attained for 127 survivors with pre-arrest VABS-II ≥70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months...Continue Reading

Citations

Sep 10, 2019·World Journal for Pediatric & Congenital Heart Surgery·Aqsa ShakoorWilliam Middlesworth
Apr 30, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ivie D EsangbedoJavier J Lasa
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katherine L Brown, Timothy Thiruchelvam
Feb 3, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Anne-Marie GuerguerianLakshmi Raman
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Anne-Marie GuerguerianLakshmi Raman
Apr 1, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Georgia BrownPeta M A Alexander

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