One-Year Follow-Up of Serum Prolactin Level in Schizophrenia Patients Treated with Blonanserin: A Case Series

Psychiatry Investigation
Sakae TakahashiMakoto Uchiyama

Abstract

In our previous study, a prolactin elevation was more frequently in risperidone than in blonanserin; however, it was more often in blonanserin than in olanzapine. Therefore, while a rate of PRL rising is low to moderate, hyperprolactinemia is a considerable adverse effect in the blonanserin treatment. In this study, to examine detailed characteristics of hyperprolactinemia of blonanserin, we analyzed the prolactin data in six schizophrenic patients who were switched to blonanserin from other antipsychotics and followed for one year. As a result, blonanserin dose was clearly associated with serum prolactin level. The average prolactin level was almost normal when the mean blonanserin dosage was 8.0 mg/day. Regardless of the dose decrease of blonanserin, there were no remarkable changes in symptoms and social functions. Based on our findings, we conclude that low dose blonanserin medication may be useful for schizophrenia maintenance treatment without hyperprolactinemia and a high rate of relapse.

References

Apr 21, 2018·Pharmacological Reports : PR·Ewa A OgłodekAdam R Szromek

Citations

Dec 25, 2009·CNS Drugs·Emma D Deeks, Gillian M Keating
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Sakae TakahashiMakoto Uchiyama

Related Concepts

PRL
Study
Other antipsychotics in ATC
Olanzapine
Follow-up
Schizophrenia
Hyperprolactinemia
7-hydroxycoumarin-3-acetic acid N-hydroxysuccinimidyl ester
Adverse Effects
Antipsychotic Agents

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