PMID: 9426102Jan 13, 1998Paper

One year follow-up study of endocrine and lung function of asthmatic children on inhaled budesonide

The European Respiratory Journal
W H NikolaizikJ O Warner

Abstract

Inhaled corticosteroids have become a mainstay in the management of chronic asthma. Their use had been considered safe, although some degree of adrenal suppression has been demonstrated after 2 and 4 weeks of treatment with either 400 microg x day(-1) of beclomethasone dipropionate or budesonide. To weigh the benefits and risks of long-term treatment, 12 children with moderately severe asthma were assessed in a follow-up study on budesonide 200 microg b.i.d. After 1 yr, the nocturnal cortisol production was significantly reduced by 19%, but no greater compared to 2 and 4 weeks of treatment. Growth and growth hormone levels were normal. Lung function tests were significantly better, not only versus baseline values but also versus 2 and 4 weeks of treatment. We conclude that systemic effects of inhaled corticosteroids in conventionally low doses do not accumulate with length of treatment, whilst lung function parameters will continue to improve. Therefore, inhaled corticosteroids once started in asthmatic children not controlled on other medications should be continued, but their use should be carefully considered and the minimal dose required to control the asthma employed.

Citations

Nov 7, 2000·Current Surgery·S HetzJ Schriver
Aug 12, 2005·Current Surgery·James H Garofalo, Walter E Pofahl
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·E DeromR Pauwels
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·L P Nielsen, R Dahl
Jun 28, 2002·Clinical Pediatrics·Sherwin A GillmanKenneth Newman

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