One-year follow-up study of psychotic patients treated with blonanserin: a case series

Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists
Sakae TakahashiMakoto Uchiyama

Abstract

Blonanserin is a relatively new atypical antipsychotic drug, and has been used in Korea and Japan for 1 and 3 years, respectively. Therefore, the clinical characteristics of blonanserin remain unclear. In this study, to clarify the features of blonanserin, we performed prospective and long-term comparative investigations of patients treated with blonanserin. We followed 10 psychiatric patients who were switched to blonanserin from other antipsychotics for 1 year (schizophrenia: 8; mental retardation: 2). In the light of quality of life, we focused on adverse effects of patients during the follow-up. In the long-term follow-up, (i) hyperprolactinemia is more frequently in risperidone than in blonanserin; however, it is more often in blonanserin than in olanzapine; and (ii) weight gain is more common in olanzapine than in blonanserin. We switched to blonanserin from other antipsychotic drugs within the same case, and then followed the case for 1 year. We consider that long-term observations within the same case lead to obvious comparisons among drugs. On the basis of our findings, we conclude that blonanserin may be useful for the maintenance treatment of schizophrenia without inducing hyperprolactinemia and weight gain.

References

Aug 15, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hirotake HidaYukihiro Noda
Jun 28, 2016·Pharmacology & Therapeutics·Gian Marco LeggioFilippo Drago

Citations

Dec 29, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·José Luis R MartinEnric Alvarez
Aug 25, 2009·Lancet·Jim van Os, Shitij Kapur
Dec 25, 2009·CNS Drugs·Emma D Deeks, Gillian M Keating

Related Concepts

Antipsychotic Effect
Atypical Antipsychotic [EPC]
Other antipsychotics in ATC
Olanzapine
Schizophrenia
Piperazines
Psychiatric Inpatient
Hyperprolactinemia
Adverse Effects
Piperidines

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