One-year high fat diet affects muscle-but not brain mitochondria

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Tenna JørgensenBjørn Quistorff

Abstract

It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown. Wistar rats were fed either chow (13E% fat) or HF diet (60E% fat) for 1 year. The HF animals developed obesity, dyslipidemia, insulin resistance, and dysfunction of isolated skeletal muscle mitochondria: state 3 and state 4 were 30% to 50% increased (P<0.058) with palmitoyl carnitine (PC), while there was no effect with pyruvate as substrate. Adding also succinate in state 3 resulted in a higher substrate control ratio (SCR) with PC, but a lower SCR with pyruvate (P<0.05). The P/O2 ratio was lower with PC (P<0.004). However, similar tests on isolated brain mitochondria from the same animal showed no changes with the substrates relevant for brain (pyruvate and 3-hydroxybutyrate). Thus, long-term HF diet was associated with obesity, dyslipidemia, insulin resistance, and significantly altered mitochondrial function in skeletal muscle. Yet, brain mitochondria were unaffected. We suggest that the relative isolation of the brain due to the blood-brain barrier may play a role in this st...Continue Reading

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Citations

Nov 7, 2016·Toxicologic Pathology·Rani S Sellers
Apr 20, 2017·International Journal of Molecular Sciences·Prasad P DevarshiTara M Henagan
May 17, 2018·Advances in Nutrition·E Madison SullivanSaame Raza Shaikh
May 5, 2020·Journal of Cellular and Molecular Medicine·Estelle HeyneMichael Schwarzer
Apr 8, 2020·Journal of Cellular and Molecular Medicine·Miriayi AlimujiangJun Yin
Dec 14, 2018·Neurochemical Research·Isabel H Salas, Bart De Strooper
Sep 11, 2020·Journal of Applied Physiology·Gisele C RodriguesPedro L Silva

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Methods Mentioned

BETA
biopsies
biopsy
sedation

Software Mentioned

Power
GraphPad Prism
ARRIVE
SAS

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