One-year observation of kidney allograft recipients converted from cyclosporine microemulsion to tacrolimus

Transplantation Proceedings
A ChamieniaB Rutkowski

Abstract

The results from previous trials suggested that tacrolimus-based treatment in kidney transplantation was associated with a significantly lower incidence of acute rejection, and that cyclosporine microemulsion (CsA-Me)-treated patients converted to tacrolimus had numerically better 6-year graft survival than those remaining on CsA-Me. Death with a functioning graft and chronic graft nephropathy are the leading causes of late allograft loss. While standard cardiovascular risk factors are relevant, renal function itself becomes an important risk factor for cardiovascular morbidity and mortality in kidney transplantation patients. Expected benefits of the conversion from CsA-Me to tacrolimus with respect to renal function and cardiovascular status were the rationale for this observational study. Twenty one patients underwent conversion due to nephrotoxicity of cyclosporine (n = 18) or side effects (n = 3). Two out of 21 patients did not complete the study. The patient survival after 1 year was 100% in this group of patients; graft survival 94.7%. No cases of de novo diabetes mellitus were identified. Mean serum creatinine fell from 2.13 +/- 0.4 to 1.84 +/- 0.3 mg/dL (P < .02) and calculated glomerular filtration rate increased from...Continue Reading

References

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Citations

Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiayu LiJianghua Chen
Apr 15, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Josef ZadrazilIvo Valkovsky
Oct 31, 2009·Immunopharmacology and Immunotoxicology·Qing Yuan LiYan Hui Mei
Sep 1, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lei PengBing Li
Jun 21, 2007·Transplantation Proceedings·S-M JiZ-H Liu
May 2, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiayu LiJianghua Chen
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F L LuanA O Ojo

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